PENGUKURAN KADAR ISONIAZID DALAM PLASMA DARAH PASIEN TBC DI BEBERAPA PUSKESMAS KABUPATEN X

Firdausi, Nadia (2017) PENGUKURAN KADAR ISONIAZID DALAM PLASMA DARAH PASIEN TBC DI BEBERAPA PUSKESMAS KABUPATEN X. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Isoniazid is the most potent tuberculosis drug in terms of killing the bacterium Mycobacterium tuberculosis. Treatment with INH for 6-12 months was used as a standard regimen in the treatment of tuberculosis. Prolonged use may lead to bacterial resistance to INH, making handling of tuberculosis more difficult. Isoniazid in vivo will reach peak plasma levels within 1-2 hours after administering 300 mg peroral doses resulting in peak plasma concentrations of 3- 5 μg / ml. This study aims to measure Isoniazid levels in blood plasma of tuberculosis patients in some Puskesmas in Kabupaten X. In this research, measurement levels of INH in blood plasma tubercolosis patients by High Performance Liquid Chromatography (HPLC) method using a reversed phase Shimpack C18 colomn and an isocratic solvent programme, mobile phase was the mixture of Kalium Dihidrogen Fosfat 15 mmol pH 6,2 : acetonitril (99:1) with a flow rate 1,0 ml/min and measurement were done at a wavelength of 230 nm. The measurement of INH levels in the blood plasma of tuberculosis patients after 2 hours of taking the drug was that not all samples reached the required peak level by theory, with mean INH levels in blood plasma of TB patients was 6,221 μg / ml. The results of statistical analysis showed that there was a difference between target INH levels and measured INH levels in plasma of TB patients. Keywords: Isoniazid, Plasma, Tuberculosis, HPLC

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Isoniazid, Plasma, Tuberculosis, HPLC
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 25 Feb 2019 02:59
Last Modified: 25 Feb 2019 02:59
URI: http://repository.setiabudi.ac.id/id/eprint/966

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