UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN BAYAM DURI (Amaranthus spinosus L.) TERHADAP MENCIT PUTIH BETINA

Arraissa, Nabila (2017) UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN BAYAM DURI (Amaranthus spinosus L.) TERHADAP MENCIT PUTIH BETINA. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Spinach leaf sprouts (Amaranthus spinosus L.) contains several nutritious compounds, One of them as a tumor drug, but there has been no research to examine the safety standards of spinach leaf extracts to test animals. This study aims to examine the effects of acute toxicity on female white mice. Acute toxicity test was performed by fixed dose method using female white mouse test as much as 30 animals divided into 6 groups, that is negative control (CMC 0,5%), dose I (5 mg / kgBB), dose II (50 mg / kgBB), dose III (300 mg / kgBB), dose IV (2000 mg / kgBB), dose V (5000 Mg / kgBW) that has been converted to the test animal for 14 days. Acute toxicity test of ethanol extract of spinach leaf was done on mice by observing the effect of extract on clinical symptoms after single dosage of test preparation, organ index, and macropathology observation of female white mice. The results of observation after giving extract in female white mice up to dosage 5000 mg/kgBB no test animals died and significant toxic effect, so the spinach leaf extract can be declared safe and LD50 pinach leaf extract on female white mice greater than 5000 mg/kgBB. Keywords: acute toxicity, Amaranthus spinosus, fixed dose method, LD50.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: acute toxicity, Amaranthus spinosus, fixed dose method, LD50.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 25 Feb 2019 02:56
Last Modified: 25 Feb 2019 02:56
URI: http://repository.setiabudi.ac.id/id/eprint/963

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