UJI AKTIVITAS ANTIBAKTERI KRIM KOMBINASI EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L.) DAN EKSTRAK ETANOL DAUN SIRIH (Piper betle L.) TERHADAP BAKTERI Staphylococcus epidermidis SECARA In Vivo

Dewi, Mulya (2017) UJI AKTIVITAS ANTIBAKTERI KRIM KOMBINASI EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L.) DAN EKSTRAK ETANOL DAUN SIRIH (Piper betle L.) TERHADAP BAKTERI Staphylococcus epidermidis SECARA In Vivo. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Soursop leaves (Annona muricata L.) and betel leaves (Piper betle L.) have antibacterial activity against Staphylococcus epidermidis. Chemical compounds contained in both of these plants that have antibacterial activity are flavonoids, tannins, and saponins. The purpose of this research was to know the ability of cream combination of ethanol extract of soursop leaves and betel leaves in curing acne due to infection of Staphylococcus epidermidis, to know the effective concentration of cream combination which could cure acne due to Staphylococcus epidermidis infection, to know the pharmacology effect of cream combination, and to know the stability of cream preparations during the research. Extraction in this research used maceration method with 70% ethanol as the solvent. The parameters of soursop leaves extract and betel leaves extract were being observed were concentration of extract combination and storage time for 21 days. The healing time was observed by observing the duration of healing of rabbit's back acne after giving cream, characterized by the loss of acne (pustules) and pus. The data which obtained were analyzed by one-way ANOVA (significant p <0.05). The results showed that ethanol extract cream of soursop leaves and betel leaves had antibacterial activity against Staphylococcus epidermidis with effective concentration ratio of soursop leaves extract was 1.25 g and betel leaves extract was 0.5 g. The stability of cream combination of ethanol extract of soursop leaves and betel leaves had good cream stability. Keywords : Soursop leaves (Annona muricata L.), betel leaves (Piper betle L.), antibacterial, cream, Staphylococcus epidermidis, acne.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Keywords : Soursop leaves (Annona muricata L.), betel leaves (Piper betle L.), antibacterial, cream, Staphylococcus epidermidis, acne.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 25 Feb 2019 02:56
Last Modified: 25 Feb 2019 02:56
URI: http://repository.setiabudi.ac.id/id/eprint/960

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