PENGARUH PEMBERIAN KOMBINASI EKSTRAK UBI JALAR UNGU (Ipomoea batatas L.) DAN GLIBENKLAMID TERHADAP AKTIVITAS ENZIM GLUTATION PEROKSIDASE PADA TIKUS DIABETES

Khasanah, Mufit Nur (2017) PENGARUH PEMBERIAN KOMBINASI EKSTRAK UBI JALAR UNGU (Ipomoea batatas L.) DAN GLIBENKLAMID TERHADAP AKTIVITAS ENZIM GLUTATION PEROKSIDASE PADA TIKUS DIABETES. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Recently, anthocyanins-rich food, is believed to prevent tissue damages due to oxidative stress. The purple sweet potato contains anthocyanin that can be used as an antioxidant. The purpose of this study was to determine the elevated activity of glutathione peroxidase enzyme. This study was used 5 groups of male wistar rats. Control I (normal group); Group II (negative control); Group III (positive control); Group IV group of purple sweet potato extract dose of 200 mg / kg BW; Group V combination with glibenklamid (purple sweet potato100 mg BW extract: glibenclamide dose of 0,045 mg kgBW). All testing group, except normal group was induced by aloksan 28 mg/200 g BW after 14 days treatment of glutathione peroxidase enzyme was measured in liver tissue of alloxan-induced mice. The data was obtained in analysis by one way anova method (p <0,05) followed by Tukey test. The results of this study should that purple sweet potato extract has the activity to increased glutathione peroxidase enzyme levels. The most effective dose of purple sweet potato extract is on the dose of 200 mg / kg BW which there is an increased of glutathione peroxidase enzyme level of 44.84 U / mg, it has significant difference with positive control. Key words : puple sweet potatoes extract, combinations with glibenclamide, antioxidant, glutation peroksidase

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Key words : puple sweet potatoes extract, combinations with glibenclamide, antioxidant, glutation peroksidase
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 23 Feb 2019 04:26
Last Modified: 23 Feb 2019 04:26
URI: http://repository.setiabudi.ac.id/id/eprint/938

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