AKTIVITAS ANTI HIPERGLIKEMIK, PENGHAMBATAN STRESS OKSIDATIF DAN REGENERASI PANKREAS, KOMBINASI EKSTRAK JAHE MERAH (Zingiber officinale) DAN DAUN SALAM (Syzygium polyanthum (Wight)Walp) PADA TIKUS YANG DIINDUKSI STREPTOZOTOSIN NIKOTINAMID

Rosalina, Vivi (2017) AKTIVITAS ANTI HIPERGLIKEMIK, PENGHAMBATAN STRESS OKSIDATIF DAN REGENERASI PANKREAS, KOMBINASI EKSTRAK JAHE MERAH (Zingiber officinale) DAN DAUN SALAM (Syzygium polyanthum (Wight)Walp) PADA TIKUS YANG DIINDUKSI STREPTOZOTOSIN NIKOTINAMID. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

The Combination of red ginger (Zingiber officinale) and bay leaf (Syzygium polyanthum (Wight)Walp) extract is beneficial for the treatment of DM. This research is aimed to find out the effect of antihyperglicemic and increasing the SOD antioxidants enzyme activity, GPx and pancreatic histopathology in STZ-NA induced rat. This research was divided into 6 group (each group consisted 5 rats). Group 1 is normal control (without treatment), 2nd negative control (induction STZ-NA), 3rd red ginger group 250mg/kg, 4th group with 300mg/kg, 5th group with red ginger 187,5mg/kg + bay leaf 75 mg/kg, 6th group with red ginger 125 mg/kg+bay leaf 150 mg/kg. The treatment had been given for 28 days. The measured parameter were glucose level, SOD, GPx and pancreatic histopathology. The glucose level was analized by statistic test one way Anova, significancy at p<0,05 continued by LSD. This research result showed group 3, 4, 5, 6 could decrease the glucose level in STZ-NA induced rat. Group 5 and 6 had good activity as antihyperglicemic, increasing the activity of SOD enzym, GPx and increasing the regenaration of Langerhans land. Keywords : Red Ginger (Zingiber officinale) and Bay Leaf (Syzygium polyanthum (Wight)Walp) Hyperglicemic activity, Improvement of Oxidative Stress, Regeneration of Pancreatic cells.

Item Type: Thesis (Tesis)
Uncontrolled Keywords: Keywords : Red Ginger (Zingiber officinale) and Bay Leaf (Syzygium polyanthum (Wight)Walp) Hyperglicemic activity, Improvement of Oxidative Stress, Regeneration of Pancreatic cells.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 23 Feb 2019 04:20
Last Modified: 23 Feb 2019 04:20
URI: http://repository.setiabudi.ac.id/id/eprint/860

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