OPTIMASI FORMULA FAST DISINTEGRATING TABLET CETIRIZINE HCL DENGAN FILLER BINDER STARCH 1500, MANITOL DAN AVICEL PH 102 DALAM KOMPLEKS INKLUSI β-SIKLODEKSTRIN METODE SIMPLEX LATTICE DESIGN

Assem, Vincentia Santy (2017) OPTIMASI FORMULA FAST DISINTEGRATING TABLET CETIRIZINE HCL DENGAN FILLER BINDER STARCH 1500, MANITOL DAN AVICEL PH 102 DALAM KOMPLEKS INKLUSI β-SIKLODEKSTRIN METODE SIMPLEX LATTICE DESIGN. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Cetirizine HCl is an antagonist of a histamine-1 receptor has used as an long-action antihistamine. Formulation of cetirizine HCl in a fast disintegrating tablet (FDT) using an inclusion complex with β-cyclodextrin is an appropriate alternative to enhance the palatability and disintegrate rapidly in the mouth. This research aimed at optimizing and evaluating the influence of starch 1500, mannitol dan avicel PH 102 on wetting time, disintegration time, friability, hardness, palatability and drug release of FDT cetirizine HCl using the inclusion complex with β-siklodekstrin. A simplex lattice design method was applied to optimize the fast disintegrating tablet of cetirizine HCl in inclusion complex with β-cyclodextrin. Avicel PH 102, Starch 1500 and mannitol were used as independent variables. The optimum area was determined using a superimposed contour plot of combination of disintegration time, wetting time, friability, hardness, the amount of drug released at 1 minute and dissolution efficiency using a Design Expert software. The result showed that starch 1500 affected on the reducing of wetting time, disintegration time and drug release. Enhancement of manitol concentration increased the mouth feel and hardness, and reduced the wetting time, disintegration time and friability. Enhancement of avicel PH 102 aid the wicking process thus reduced the disintegration time. Interactions between manitol and avicel PH 102, starch 1500 and avicel PH 102, and interaction of three variables reduced the wetting time and drug release. The optimized formulae of FDT cetirizine HCl with β-cyclodextrin complexation was obtained at mannitol of 103.22 mg, avicel PH 102 of 11.78 mg, and absence of Starch proportion in fillerbinder composition. Key words: FDT, cetirizine HCl, β-siklodekstrin, Starch 1500, Manitol, Avicel PH 102, simplex lattice design.

Item Type: Thesis (Tesis)
Uncontrolled Keywords: Key words: FDT, cetirizine HCl, β-siklodekstrin, Starch 1500, Manitol, Avicel PH 102, simplex lattice design.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 23 Feb 2019 04:20
Last Modified: 23 Feb 2019 04:20
URI: http://repository.setiabudi.ac.id/id/eprint/857

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