FORMULASI DAN KARAKTERISASI NANOKAPSUL MINYAK BIJI MAHONI DENGAN METODE EMULSI SONIKASI

ASWADI, Muhamad Nur (2018) FORMULASI DAN KARAKTERISASI NANOKAPSUL MINYAK BIJI MAHONI DENGAN METODE EMULSI SONIKASI. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Oils of mahogany seed is not soluble in water consequently it was difficult to applied to inappropriate in the product of food and are first of all the less volatile with respect to heat, UV ray, and moisture so that it can easily has experienced a fall in the activity of but. One of the approaches the solubility of and stability is nanocapsule. This study aims to in order to understand the a method of an emulsion sonication to be able to produce nanocapsule with the stability of the country and characterization as it seemed good to a variety of the kinds of polymer . The process of nanocapsule oils of mahogany seed have been carried out with a method of an emulsion sonication as long as 2 minutes to turn to be nanometer size employing variations the type and the concentration of a polymer PVA and final day of formula , Na-alginat , and HPMC consecutive 3% ; 0,4% ; 0,3% by concentration of the tween 80 still 3%. Preparations nanocapsule from a formula tested size of particles, zeta potencial, percent transmitan, and the stability take in freeze-thaw cycle test, and centrifugation test. The results showed oils of mahogany seed can be made into nanocapsule preparations. Size of nanocapsule efficiency was obtained from formula 1, 2, and 3 by 195,6±4,979 nm, 419,9±33,75 nm, dan 328,4±32,57 nm. Nanocapsule concentration of polymer Na-alginat 0,4% with time sonication two minutes the results size of particles of 419,5±33,75 nm, polidispersity index 0,501±0,009 to 495,5±81,13 nm, polidispersity index 0,488±0,108, and zeta potential of 74,1±3,11 mV so elected measure, uniformity, and stability which is best compared to other formula. Keywords: Mahogany seed oil, nanocapsule, Na-Alginate polymer, sonication

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Mahogany seed oil, nanocapsule, Na-Alginate polymer, sonication
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 23 Feb 2019 04:18
Last Modified: 23 Feb 2019 04:18
URI: http://repository.setiabudi.ac.id/id/eprint/828

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