AKTIVITAS ANTIASMA REBUSAN KOMBINASI DAUN SEMBUNG (Blumea balsamifera L. DC.), HERBA PATIKAN KEBO (Euphorbia hirta L.), BIJI KEMUKUS (Piper cubeba L.), DAN RIMPANG TEKI (Cyperus rotundus Linn.) PADA MARMUT JANTAN SECARA IN VITRO DAN IN VIVO

Damayanti, Kiki (2017) AKTIVITAS ANTIASMA REBUSAN KOMBINASI DAUN SEMBUNG (Blumea balsamifera L. DC.), HERBA PATIKAN KEBO (Euphorbia hirta L.), BIJI KEMUKUS (Piper cubeba L.), DAN RIMPANG TEKI (Cyperus rotundus Linn.) PADA MARMUT JANTAN SECARA IN VITRO DAN IN VIVO. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Empirically, combination of decoction of sembung leaves, patikan kebo herbs, kemukus fruits, and teki rhizomes has been used to relief asthma. Individually, sembung leaves, patikan kebo herbs, kemukus fruits, and teki rhizomes known had activity as antiasthma. The goal of the research are to assess the activity of combination of decoction as antiasthma in vitro and in vivo. The antiasthma activity testing in vitro is done using isolated guinea pig traceal muscle. Histamin, KCl, and CaCl2 used as contraction inductor to guinea pig tracheal muscle. The antiasthma activity testing in vitro is done using guinea pig as asthma animal model. Asthma inductor was subcutan and nebulation of ovalbumin. Asthma guinea pig were given combination of decoction for 29 days. Tracheal smooth muscle stained with toluidine blue and hematoxilin eosin to count undegranulated mast cell, eosinophils, and edema. The research showed that combination of decoction of four plants had antiasthma activity in vitro as H1 receptor antagonist. In vivo, the combination of decoction had no effect as mast cell stabilizer, eosinophil infiltration inhibition, and edema inhibitation. Key words : sembung leaves, patikan kebo herbs, kemukus fruits, teki rhizomes, antiasthma

Item Type: Thesis (Tesis)
Uncontrolled Keywords: Key words : sembung leaves, patikan kebo herbs, kemukus fruits, teki rhizomes, antiasthma
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 23 Feb 2019 04:15
Last Modified: 17 Sep 2020 07:45
URI: http://repository.setiabudi.ac.id/id/eprint/804

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