SINTESIS SENYAWA ANALOG KALKON DENGAN MATERIAL AWAL 3,4-DIKLOROASETOFENON DAN INDOL-3-KARBALDEHID MENGGUNAKAN KATALIS NaOH DALAM PELARUT ETANOL

Islami, Rosa Pangestika (2016) SINTESIS SENYAWA ANALOG KALKON DENGAN MATERIAL AWAL 3,4-DIKLOROASETOFENON DAN INDOL-3-KARBALDEHID MENGGUNAKAN KATALIS NaOH DALAM PELARUT ETANOL. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Chalcones are considered as the precursors of flavonoids which consist of two aromatic rings linked by a three-carbon α,β-unsaturated carbonyl system. Chalcone and its analogues have been reported to possess various biological activities such as antibacterial, anticancer, antifungal, anti-inflammatory and antioxidant. The aim of this study was to synthesize 3-(3-indolyl)-1-(3,4dichlorophenyl)prop-2-en-1-one using indole-3-carboxaldehyde and 3,4dichloroacetophenone as starting materials. 3-(3-indolyl)-1-(3,4-dichlorophenyl)prop-2-en-1-one was synthetized from indole-3-carboxaldehyde and 3,4-dichloroacetophenone, catalyzed by NaOH in ethanol solvent. Thin layer and gas chromatography were used as purity test method. The structure of the compound was elucidated using mass spectrometer, UV-Vis spectrophotometer and IR spectrophotometer. The results showed that 3-(3-indolyl)-1-(3,4-dichlorophenyl)prop-2-en-1one was successfully synthesized, yellow powder was obtained with 15,37% of yield and 100 % of purity. Structure elucidation showed that the chemical structure was appropriate to estimated chemical structure. Keywords : synthesis, 3-(3-indolyl)-1-(3,4-dichlorophenyl)prop-2-en-1-one, NaOH, indole-3-carboxaldehyde, 3,4-dichloroacetophenone, chalcone analogue

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: synthesis, 3-(3-indolyl)-1-(3,4-dichlorophenyl)prop-2-en-1-one, NaOH, indole-3-carboxaldehyde, 3,4-dichloroacetophenone, chalcone analogue
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: magdalena kartika ningsih
Date Deposited: 23 Feb 2019 04:14
Last Modified: 23 Feb 2019 04:14
URI: http://repository.setiabudi.ac.id/id/eprint/796

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