AKTIVITAS ANTITUSIF DAN EKSPEKTORAN EKSTRAK ETANOL, FRAKSI POLAR-SEMI POLAR HERBA MENIRAN (Phyllanthus niruri L.) PADA MARMUT (Cavia porcellus)

Fakharuddin, Fakharuddin (2017) AKTIVITAS ANTITUSIF DAN EKSPEKTORAN EKSTRAK ETANOL, FRAKSI POLAR-SEMI POLAR HERBA MENIRAN (Phyllanthus niruri L.) PADA MARMUT (Cavia porcellus). Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Phyllantus niruri L., is wild plants, has wide applications in traditional medicine. The purpose of this study is to evaluated antitussive, expectorant activity, and description antitussive mechanism of phyllantus herbs. Test animal male guniea pigs as many as 36 divided into 9 groups each consisting of 4 guinea pigs. The antitussive activity of ethanol extract and fraction F, G be observed on percentage cough suppression by giving a citric acid 7.5% for 5 days. The Expectorant activity was evaluated with phenol red concentration in guinea trachea on 7 days. The mechanism description is evaluated by looking at the comparison of phyllantus herbs and combination ethanol extract phyllantus herbs and codeine modulated by the opioid receptor and glibenclamide modulated by the ATP sensitiv.e K+ channel. The research showed ethanol extract and fraction F, G increased the suppression of citric acid induced by citric acid 7.5% and decreased the a supprssant of mucus secretion on evaluation of expectorant. Fraction F, G 160 mg/kgBB showed the effective activity antitussive 63,57%. Fraction F, G 80 mg/kgBB showed decreased phenol red secretion by 56,91%. This study provides evidence that phyllantus herbs can be used as an antitussive and a suppressant of mucus secretion. Phyllantus herbs not description on mechanism antitussive modulated by the opioid receptor and ATP sensitiv.e K+ channel. The antitussive mechanism may be modulated by other systemic nerves and peripheral nerves. Keywords: Phyllantus niruri L., citric acid, antittusive, expectorant.

Item Type: Thesis (Tesis)
Uncontrolled Keywords: Keywords: Phyllantus niruri L., citric acid, antittusive, expectorant.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 23 Feb 2019 04:13
Last Modified: 23 Feb 2019 04:13
URI: http://repository.setiabudi.ac.id/id/eprint/784

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