EFEK ANTIHIPERGLIKEMIK DAN PERBAIKAN FUNGSI GINJAL EKSTRAK ETANOL BIJI KETUMBAR (Coriandrum sativum L.) PADA TIKUS DIABETES NEFROPATI YANG DIINDUKSI STREPTOZOTOSIN-NIKOTINAMID

Novia, Devi (2017) EFEK ANTIHIPERGLIKEMIK DAN PERBAIKAN FUNGSI GINJAL EKSTRAK ETANOL BIJI KETUMBAR (Coriandrum sativum L.) PADA TIKUS DIABETES NEFROPATI YANG DIINDUKSI STREPTOZOTOSIN-NIKOTINAMID. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Diabetes mellitus is a metabolic disease with hyperglycemia as the characteristic which is possible to cause various chronic complications such as diabetic nephropathy. An injection of streptozotosin in guinea pig causes some damage on pancreatic beta cell and kidney. This research purpose is to find out the effect of an adduction of ethanol extract of coriander fruits in reducing blood glucose level, BUN, creatinine, albuminuria, and histopathology of kidney organs in mice which is induced with streptozotosin-nikotinamid. This study used 25 male wistar rats induced with intraperitoneeal injection of STZ-NA with dosage 60mg/kg BW and 120 mg/kg BW, divided into 5 group. Rats diagnosed DM for 26 days were injected with STZ-NA and orally given with the extract for one month. The parameter which is measured are the blood glucose level, BUN, creatinine and albuminuria. Data analysis used ANOVA test method and continued with LSD Post Hoc test. Statistic analysis result of the level BUN revealed there was a significant difference between the extract group and negative group however there was no significant difference between the extract with 250mg/kg BW to the extract with 500 mg/kg BW. GDP, creatinine and albuminuria showed there was a significant difference between the extract group and the negative group however there was no significant difference between the extract with 500 mg/kg BB to the positive control, which meant the coriander extract has a same effect with the positive control. Keywords : DM, Ethanol Extract of Coriander Fruits, Diabetic Nephropathy, STZ-NA

Item Type: Thesis (Tesis)
Uncontrolled Keywords: Keywords : DM, Ethanol Extract of Coriander Fruits, Diabetic Nephropathy, STZ-NA
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 23 Feb 2019 03:33
Last Modified: 23 Feb 2019 03:33
URI: http://repository.setiabudi.ac.id/id/eprint/765

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