AKTIVITAS ANALGETIK DAN ANTI-INFLAMASI FRAKSI-FRAKSI EKSTRAK ETANOL DAUN GANDARUSA (Justicia gendarussa Burm. f) SECARA IN VIVO DAN UJI KEAMANAN TERHADAP LAMBUNG

Hesturini, Rosa Juwita (2016) AKTIVITAS ANALGETIK DAN ANTI-INFLAMASI FRAKSI-FRAKSI EKSTRAK ETANOL DAUN GANDARUSA (Justicia gendarussa Burm. f) SECARA IN VIVO DAN UJI KEAMANAN TERHADAP LAMBUNG. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Gandarusa (Justicia gendarussa Burm. f) is a potential plant as analgetic and anti-inflammatory activities. The aim of the present research was to investigate the analgetic activity with tail flick method and anti-inflammatory activity induced by carragenan of ethanol extract and the fractions, and to determine the safety of the stomach. Partitioned fractinations isolated from ethanolic extract of J. gendarusa leaves with n-heksana, etil asetat and water. The analgetic test was evaluated using tail flick method and the anti-inflammatori test was evaluated using the carragenan-induced rat models. The safety effect of stomach was observated by macroscopic and microscopic. Dosage extracts and fractions gandarusa leaf, respectively, are 250 mg/kg bw, 500 mg/kg bw, n-hexane fraction of 314 mg/kg bw, the fraction of 41,05 mg/kg bw and water fractions 144,8 mg/kg bw, the negative control group CMC 0.5% and aspirin 360 mg/kg bw. The results showed the ethanolic extract, fraction of n-hexane, ethyl acetate fraction and water fraction have activity as an analgesic and antiinflammatory. Ethyl acetate fraction showed analgesic activity with %antinociceptive 82,73% and anti-inflammatory with %DAI 53,03% comparable to aspirin and showed comparable safety in the stomach with a negative control. The preliminary phytochemical analisys showed the presence of active phytochemical such as flavonoids, alkaloids, saponins, steroids dan tannins and these compound might be responsible for analgetic and anti-inflammatory mechanism. The possible analgetic and anti-inflammatory mechanism of the justicia gendarussa may be through its stimulate lipomodulin protein biosynthesis which inhibit the action of phospolipase enzimatic that affecting the enzyme activity arachidonic acid but there is also has gastroprotective activity with increased mucus production and prevents the release of histamine. Keywords : Gandarusa leaf, justicia gendarussa, analgetic, anti inflammatory, carragenan, tail flick.

Item Type: Thesis (Tesis)
Uncontrolled Keywords: Keywords : Gandarusa leaf, justicia gendarussa, analgetic, anti inflammatory, carragenan, tail flick.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 23 Feb 2019 03:29
Last Modified: 23 Feb 2019 03:29
URI: http://repository.setiabudi.ac.id/id/eprint/718

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