PENGARUH PEMBERIAN SARI BUAH TERONG BELANDA (Cyphomandra betacea Sendtn.) TERHADAP KADAR BILIRUBIN DAN AKTIVITAS ALP TIKUS PUTIH JANTAN YANG DIINDUKSI ISONIAZID DAN RIFAMPISIN

Siswoyo, Haryanty Dwi (2016) PENGARUH PEMBERIAN SARI BUAH TERONG BELANDA (Cyphomandra betacea Sendtn.) TERHADAP KADAR BILIRUBIN DAN AKTIVITAS ALP TIKUS PUTIH JANTAN YANG DIINDUKSI ISONIAZID DAN RIFAMPISIN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Isoniazid and rifampicin are the dominant TB drug use and provide optimal results in the treatment. The side effects of the use of isoniazid and rifampicin are hepatotoxic. Terong belanda contains flavonoids, tannins, vitamin C, vitamin E and β-carotene can protect the liver. The purpose of this study to determine the effect and optimal dose in terong belanda to prevent hepatotoxicity by preventing the increase in bilirubin and ALP activity. Thirty rats were divided into six groups, normal control group was given 0.5% CMC.Negative control group were given INH and rifampin 50 mg / kg. The positive control group were given INH and rifampin as well as methicol® 22,5mg / kg.The first treatment group were given terong belanda juice 17.5 g / kg. The second treatment group were given juice 35 g / kg and a third treatment group were given juice 70g / kbBB. Each treatment group for 21 days and ALP and bilirubin measurements were taken on 0th,7th,14th,21th day. Data were analyzed by two-way ANOVA test and post hoc LSD. Statistical data analysis showed a significant reduction in ALP and bilirubin in the treatment group.The best dose in lowering levels of ALP and bilirubin-induced rat INH and rifampicin was 70 g / kg. Keywords: Chypomandra betacea Sendtn, isoniazid, rifampisin, ALP, Bilirubin.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Chypomandra betacea Sendtn, isoniazid, rifampisin, ALP, Bilirubin.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: magdalena kartika ningsih
Date Deposited: 23 Feb 2019 03:22
Last Modified: 23 Feb 2019 03:22
URI: http://repository.setiabudi.ac.id/id/eprint/677

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