FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI COLD CREAM TUNGGAL DAN KOMBINASI EKSTRAK DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DAN DAUN PEGAGAN (Centella asiatica (L.) Urban) TERHADAP Staphylococcus aureus ATCC 25923

Sudirman, Wige (2019) FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI COLD CREAM TUNGGAL DAN KOMBINASI EKSTRAK DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DAN DAUN PEGAGAN (Centella asiatica (L.) Urban) TERHADAP Staphylococcus aureus ATCC 25923. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Staphylococcus aureus is the cause of 51% of pyogenic infections of the skin. Whistle infections caused by Staphylococcus aureus are ulcers, pimples, and infections of the wound. One alternative treatment for skin infections due to Staphylococcus aureus is extract from binahong leaves (Anredera cordifolia (Ten.) Steenis) and pegagan leaves (Centella asiatica (L.) Urban). Both extracts have been studied in vitro and in vivo has the ability to cure infections due to effective Staphylococcus aureus. This study aims to determine whether the combination of binahong leaves and pegagan leaves can be formulated in the form of cold cream preparations, how the physical quality of cold cream is combined and how its antibacterial activity on rabbit skin is induced by Staphylococcus aureus. Binahong leaves and pegagan leaves are extracted using the remaseration method. Both extracts were tested for the content of flavonoids, alkaloids, saponins and tannins. Both extracts are formulated into cold cream preparations singly and in combination with the basis of cera alba, cetaceum, liquid paraffin and water. Single cold cream contains 5% extract of binahong leaves or pegagan leaves. Cold cream combination contains 2.5% binahong leaf extract and 2.5% pegagan leaf extract. Cold cream was tested for physical quality in the form of organoleptic, viscosity, pH, dispersion and adhesion, and the stability test of the freeze thaw method. Antibacterial activity test was carried out on rabbit skin induced by Staphylococcus aureus and observed erythema diameter, edema thickness and presence of pus. Observational data were tested statistikally using Komogorov-Smirnov, followed by Two-way ANOVA test or Kruskal-Wallis test and Mann-Whitney test. The results of the observation showed that the second combination of extracts can be formulated in the form of cold cream. The physical quality of combination cold cream organoleptically, viscosity, pH, dispersion and adhesion are said to be good. The stability test of the freeze thaw method showed a stable cold cream combination in 5 test cycles. The healing power of combination cold cream on rabbit skin is the best compared to a single cold cream. Keywords : Binahong Leaves (Anredera cordifolia (Ten.) Steenis), Pegagan Leaves (Centella asiatica (L.) Urban), Cold cream, Antibacterial, Staphylococcus aureus

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Binahong Leaves (Anredera cordifolia (Ten.) Steenis), Pegagan Leaves (Centella asiatica (L.) Urban), Cold cream, Antibacterial, Staphylococcus aureus
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Mrs NOVI HANDAYANI
Date Deposited: 16 Nov 2019 03:14
Last Modified: 16 Nov 2019 03:14
URI: http://repository.setiabudi.ac.id/id/eprint/3910

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