FORMULASI DAN KARAKTERISASI NANOFITOSOM MYRICETIN DENGAN METODE HIDRASI LAPIS TIPIS-SONIKASI

Yuvita, Vilza Dwiki (2019) FORMULASI DAN KARAKTERISASI NANOFITOSOM MYRICETIN DENGAN METODE HIDRASI LAPIS TIPIS-SONIKASI. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Myricetin is a natural flavonoid has efficacious as antioxidants. Myricetin has very low systemic bioavailability of 10-44%, it is due to low water solubility (0.002 mg/ml). Low myricetin permeability is overcome using nanofitosom drug delivery system to increase drug penetration in the skin. The study was determined the effect of the variation of phosphatidylcholine concentration on the quality of nanofitosom myricetin in terms of particle size, adsorption efficiency, nanofitosom stability and morphology. Nanofitosom myricetin was made by thin layer hidration and sonication method, the myricetin, phosphatidylcholine and cholesterol evaporated in a round bottom flask. The thin layer formed is hydrated with a solution of Phosphate Buffer Saline, then is modified to form a homogeneous mixture and reduce the particle size. This study made 5 formulas with a comparison of the components of myricetin: phosphatidylcholine: cholesterol 1: 1: 0.2; 1: 2: 0.2; 1: 3: 0.2; 1: 4: 0.2; and 1: 5: 0.2. Characterization of myricetin nanofitosom includes particle size, adsorption efficiency, nanofitosom stability and morphology. The results of the study that myricetin can be made by the thin layer hidration and sonication method. The comparison of myricetin with phosphatidylcholine 1:5 produces smaller particle sizes. Characterization of myricetin nanofitosom produced average particle sizes in F1, F2, F3, F4 and F5, respectively 916, 593, 171, 207 and 139 nm. The highest absorption efficiency in formulas 3, 4 and 5 are 88.57%, 91.12% and 91.54% respectively. The best stability test is F5 because it does not experience precipitation for more than 3 weeks. The average particle size at F5 after storage was 164.96 nm and polydispersity index 0.3932. Potential zeta -6.35 mV so that nanofitosom myricetin was less stable during the storage process. Keywords:Cholesterol, Myricetin, Nanofitosom, Phosphatidylcholine, PSA, Sonication, Thin layer Hydration.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Cholesterol, Myricetin, Nanofitosom, Phosphatidylcholine, PSA, Sonication, Thin layer Hydration
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Mrs NOVI HANDAYANI
Date Deposited: 16 Nov 2019 02:49
Last Modified: 16 Nov 2019 02:49
URI: http://repository.setiabudi.ac.id/id/eprint/3901

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