PENGARUH EKSTRAK ETANOL UMBI BAWANG PUTIH (Allium sativum Linn) TERHADAP PENURUNAN KADAR GLUKOSA SECARA IN VITRO

Sarwanti, Gading Dyah (2019) PENGARUH EKSTRAK ETANOL UMBI BAWANG PUTIH (Allium sativum Linn) TERHADAP PENURUNAN KADAR GLUKOSA SECARA IN VITRO. Karya Tulis Ilmiah thesis, Universitas Setia Budi Surakarta.

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Abstract

Garlic (Allium Sativum L) contents of 65% of water, 28% of carbohydrate (especially fructose), 2.3% organ sulfur (mainly alliinase and ajoene), 2% protein, 1.2% amino acids (especially arginine). The pharmacological effect of garlic came from allysine, which served as an antidiabetic. This research was conducted to determine the most of effective glucose and garlic extract concentration of sugar. This study was conducted against the influence of garlic tuber extract in vitro using UV-Vis spectrophotometry with the Somogyi-Nelson method and read at a wavelength of 755 nm. The validation of this research method obtained the result of accuracy test with reacquisition value 101.62%; 97.33%; and 100.51%. The values of LOD and LOQ which were obtained, were 2.3095 and 6.9985. The results of this study obtained the rate of glucose declined due to the influence of garlic tuber extract concentration 62.5 ppm by 11.93%, 125.0% concentration of 13.69%, 250.0 ppm concentration of 19.91% and a concentration of 500.0 ppm of 9.16%. The results of the study were the highest levels of glucose lowering at a concentration of 250.0 ppm extract and the lowest at the extract concentration was 500.0 ppm. This was due to the relationship of dose and efficiency, if a drug chemical or herbal medicine as traditional herb would give a significant upsurge in pharmacological effect at a certain dose range. However, up to a certain dose of the effect of the drug did not show the significant improvement even though the dose was added. Keywords: Glucose Levels, Garlic Tuber Extract, Somgyi-Nelson method, UV-Vis Spectrophotometry

Item Type: Thesis (Karya Tulis Ilmiah)
Uncontrolled Keywords: Glucose Levels, Garlic Tuber Extract, Somgyi-Nelson method, UV-Vis Spectrophotometry
Subjects: Q Science > QL Zoology
Divisions: Fakultas Farmasi > Prodi D3 Farmasi
Depositing User: Mrs NOVI HANDAYANI
Date Deposited: 16 Nov 2019 02:26
Last Modified: 16 Nov 2019 02:26
URI: http://repository.setiabudi.ac.id/id/eprint/3755

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