UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN WANI (Mangifera caesia Jack.) TERHADAP TIKUS GALUR WISTAR YANG DIINDUKSI ALOKSAN

Puryani, Ida (2019) UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN WANI (Mangifera caesia Jack.) TERHADAP TIKUS GALUR WISTAR YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi.

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Abstract

Wani (Mangifera cesia Jack.) Is one tropical fruit plant that is closely related to mangoes. Mangoes are known to have antidiabetic abilities. The purpose of this study was to determine the antioxidant activity of ethanolic extract of Wani leaves (Mangifera caesia Jack.) In DPPH (1,1-diphenyl-2- picylhydrazil) in vitro and to find out the antioxidant activity of glutathione peroxidase enzyme ethanolic extract of wani leaves in wistar strain rats which induced alloxan. Wani leaf powder macerated by ethanol coating. The ethanol extract of Wani leaves was tested for antioxidant activity using the DPPH (1,1-diphenyl-2picylhydrazil) method and the glutathione peroxidase activity test. Antioxidant activity test of Wani leaves in test animals is by measuring the levels of glutathione peroxidase (GPx) enzyme after administration of Wani leaf extract in hyperglycemic wistar strain rats, where negative control (cmc 0.5% suspension), positive control (glibenclamide), Wani leaf extract with a dose of 125, 250, 500 mg / kgBB. hepar rhyme taken and measured antioxidant levels of glutathioneperoxidase (GPx) enzyme. Glutathione peroxidase levels were analyzed using oneway ANOVA test and post hoc test. The results showed that the ethanol extract of Wani leaves had antioxidant activity in DPPH in-vitro with an IC50 value of 35,399 ppm where the value was included in the group of highly active antioxidants. The administration of Wani leaf extract can increase glutathione peroxidase activity in alloxan-induced rats, best at a dose of 500 mg / kgBB. Keywords: Alloxan, Antioxidants, ethanol extract of Wani leaves, DPPH, Glutathione peroxidase (GPx)

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Alloxan, Antioxidants, ethanol extract of Wani leaves, DPPH, Glutathione peroxidase (GPx)
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 04 Nov 2019 03:47
Last Modified: 04 Nov 2019 03:47
URI: http://repository.setiabudi.ac.id/id/eprint/3683

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