FORMULASI DAN KARAKTERISASI SOLID LIPID NANOPARTICLE MYRISETIN DENGAN METODE ULTRASONIKASI

Rosida, Dewi Zulfa (2019) FORMULASI DAN KARAKTERISASI SOLID LIPID NANOPARTICLE MYRISETIN DENGAN METODE ULTRASONIKASI. Skripsi thesis, Universitas Setia Budi.

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Abstract

Mirisetin is a flavonoid compound that has natural antioxidant activity but has a low solubility and dissolution rate. This study aims to increase the solubility of myristetin with the form of Solid Lipid Nanoparticles (SLN). SLN were formulated, using imwitator 941, dynasan 118 and apifil as solid lipids with different concentrations and tween 80 by ultrasonication. Characterization SLN were evaluated using particle size measurement, polydispersity index, entrapment efficiency, zeta potential, and antioxidant activity by DPPH. The results showed that myiricetin can be made with the preparation of Solid Lipid Nanoparticles with apifil 2% (F7) as lipid and tween 80 as surfactant by the ultrasonication method, can produce the smallest particle size 105.5 ± 0.70 ; zeta potential -20.52 mV, the storage stability SLN was one week; efficiency entrapment 73.56% and has antioxidant activity with IC50 38.77 ppm Key words: Apifil, myricetin, SLN, ultrasonication

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Apifil, myricetin, SLN, ultrasonication
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Nov 2019 03:36
Last Modified: 01 Nov 2019 03:36
URI: http://repository.setiabudi.ac.id/id/eprint/3613

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