PENGARUH LIQUID DAN SOLID STATE SUPERSATURABLE SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) TERHADAP DIFUSI PITAVASTATIN

Dwiningtyas, Dela (2019) PENGARUH LIQUID DAN SOLID STATE SUPERSATURABLE SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) TERHADAP DIFUSI PITAVASTATIN. Skripsi thesis, Universitas Setia Budi.

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Abstract

Pitavastatin is a statin category with low solubility and bioavailability and experiences first-past metabolism. S-SNEDDS method is a new alternative combines of the SNEDDS system and solid preparations. SNEDDS system can increase the solubility medicine can't soluble in water while the S-SNEDDS benefits from the stability and flexibility production process. SNEDDS and S- SNEDDS diffusion tested. Testing aims to know the difference between SNEDDS and SSNEDDS in the ability to pass through the membrane. SNEDDS pitavastatin preparation with oil composition, surfactant and co-surfactant that is capriyol, tween 80 and transcutol P. The stability of SNEDDS can be increased by added adsorbents. Solidification technique with adsorption to carrier used mesoporous mannitol can increase its bioavailability. Tested characterization included: globule size, zeta potential, drug load, emulsification time and percent transmittance. Pitavastatin SNEDDS and S-SNEDDS was tested results were carried out diffusion tested used horizontal franz diffusion cells with tested parameters: speed and diffused amount of medicine. Nanoemulsion of a liquid SNEDDS pitavastatin was produce emulsification time 5.30 ± 0.19 seconds, 90.55 ± 6.28 mg / ml drug loading, 97.3 ± 0.26% transmittance and 69.7 nm particle size. Pitavastatin of a solid SNEDDS was produce emulsification time 8.56 ± 0.23 seconds, drug loading 26.27 ± 1.21 mg / ml, transmittance 63.3 ± 0.32% and particle size 185.2 nm. Pitavastatin of a solid SNEDDS was produce diffusion tested with phosphate buffer pH 7.4 reached 105.86% higher than pitavastatin was SNEDDS liquid that is 67.64%. Keyword: Pitavastatin, Liquid SNEDDS, Solid SNEDDS. Franz diffusion.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Pitavastatin, Liquid SNEDDS, Solid SNEDDS. Franz diffusion.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Nov 2019 03:34
Last Modified: 01 Nov 2019 03:34
URI: http://repository.setiabudi.ac.id/id/eprint/3591

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