AKTIVITAS EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana L.) DAN -MANGOSTIN TERHADAP KADAR INSULIN PADA TIKUS HIPERGLIKEMI

Saristiana, Yuneka (2019) AKTIVITAS EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana L.) DAN -MANGOSTIN TERHADAP KADAR INSULIN PADA TIKUS HIPERGLIKEMI. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Diabetes mellitus is characterized by hiperinsulinemia and hyperglycemia. Mangosteen pericarp is a traditional medicine that contains antioxidants of xanthon. The previous study found that mangosteen pericarp extract can provide hypoglycemic effects in diabetes. The purpose of this study was to determine the effect of mangosteen pericarp extract and -mangostin on insulin and blood glucose levels in diabetic rats. This study used 12 groups of rats, which consisted of extract treatment groups: normal control, negative control, positive control (glibenclamide), mangosteen pericarp extract at a dose of 25 mg/kg, 50 mg/kg, 100 mg/kg, and isolate treatment groups: normal control, negative control, positive control (glibenclamide), -mangostin dose 0.032 mg /200gr BW Rats, 0.064 mg / 200gr BW Rats, 0.13 mg / 200gr BW Rats. The rats treatment were diabetic, with STZ-Na induction. Mangosteen pericarp extract and -mangostin are administered orally and are seen as having an effect on decreasing blood glucose levels and increasing insulin levels after 28th day. The results showed that ethanol extract of mangosteen pericarp and -mangostin can decrease glucose levels and increase insulin levels. The results showed that the treatment group was significantly different from negative control (p <0.05) and the -mangostin dose group was 0.13 mg / 200gr BB Rat. The result of glucose level reduction and the increase in insulin levels was the best that approached positive control (p>0,05). Key words : Garcinia mangostana L, diabetic melitus, streptozotosin, nikotinamid, glibenclamid

Item Type: Thesis (Tesis)
Uncontrolled Keywords: Garcinia mangostana L, diabetic melitus, streptozotosin, nikotinamid, glibenclamid
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Mrs NOVI HANDAYANI
Date Deposited: 01 Nov 2019 07:28
Last Modified: 01 Nov 2019 07:28
URI: http://repository.setiabudi.ac.id/id/eprint/3462

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