OPTIMASI FORMULA SABUN MANDI CAIR EKSTRAK ETANOL KAYU SECANG (Caesalpinia sappan L.) DENGAN KOH, ASAM STEARAT DAN ASAM SITRAT MENGGUNAKAN METODE SIMPLEX LATTICE DESIGN DAN EFEK ANTIBAKTERINYA TERHADAP Stapylococcus aureusATCC 25923

Nurhayati, Nurul (2019) OPTIMASI FORMULA SABUN MANDI CAIR EKSTRAK ETANOL KAYU SECANG (Caesalpinia sappan L.) DENGAN KOH, ASAM STEARAT DAN ASAM SITRAT MENGGUNAKAN METODE SIMPLEX LATTICE DESIGN DAN EFEK ANTIBAKTERINYA TERHADAP Stapylococcus aureusATCC 25923. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

The most widely used soap is soap from sodium salt, but potassium soap is a softer and more soluble soap in water, so potassium soap is made for special functions, such as liquid soap. Brazilin in secang wood extract (Caesalpinia sappan L.) has potential as an antioxidant and antibacterial agent. The physical properties of liquid bath soap are determined from the base, the bases that are often used in making liquid bath soap are KOH, stearic acid, and citric acid. This study aims to determine the effect of a combination of KOH, stearic acid, and citric acid on the physical properties of liquid bath soap, determine the composition of the optimum formula, antibacterial activity and irritation testing. Secang wood dry powder was extracted with 96% ethanol, thickened and then extracts tested. Fourteen liquid soap formulas using 0.2% secang wood extract with variations of KOH base, stearic acid, and citric acid were tested for physical properties including viscosity, pH, and free alkali. The optimum formula was obtained by Simplex Lattice Design method, the results were analyzed by software design expert. The optimum formula was tested for physical properties then analyzed using one-sample t-test and irritation test. The optimum formula of liquid bath soap secang wood extract containing KOH 0.6121%, stearic acid 0.613% and citric acid 0.085% with physical properties of viscosity of 9.69, pH of 9.95 free alkali of 0.08. The optimum formula liquid bath soap can inhibit S. aureus ATCC 25923 as large as 32.6 ± 0.75 mm. T test results showed no significant difference between the response of the physical properties of the experimental results and software predictions. The optimum formula for shower bath liquid wood extract does not irritate the skin. Keywords: Secang Wood, Liquid Soap Optimization, Simplex Lattice Design

Item Type: Thesis (Tesis)
Additional Information: Secang Wood, Liquid Soap Optimization, Simplex Lattice Design
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Mrs NOVI HANDAYANI
Date Deposited: 01 Nov 2019 07:29
Last Modified: 17 Sep 2020 07:46
URI: http://repository.setiabudi.ac.id/id/eprint/3451

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