UJI AKTIVITAS ANTIHIPERGLIKEMI DAN REGENERASI SEL β PANKREAS FRAKSI-FRAKSI DARI EKSTRAK BIJI OYONG (Luffa acutangula L. Roxb) TERHADAP TIKUS YANG DIINDUKSI STREPTOZOTOSIN-NIKOTINAMID

Fadel, Muhammad Nurul (2019) UJI AKTIVITAS ANTIHIPERGLIKEMI DAN REGENERASI SEL β PANKREAS FRAKSI-FRAKSI DARI EKSTRAK BIJI OYONG (Luffa acutangula L. Roxb) TERHADAP TIKUS YANG DIINDUKSI STREPTOZOTOSIN-NIKOTINAMID. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Diabetes mellitus (DM) is a disease characterized by chronic hyperglycemic conditions and abnormalities in carbohydrate, fat and protein metabolism caused by abnormalities in insulin secretion, insulin work and both. The purpose of this study was to determine the effect of ethanol extract and oyong seed fractions to reduce glucose levels and pancreatic β cells regeneration of STZ-NA induced DM rats. This study used 35 male white wistar rats divided into 7 groups, the normal group, negative control group (CMC 0.5%), positive control group (gliclazid), oyong seed ethanol extract group dose 200 mg/Kg BW, water fraction group dose 84,82 mg/Kg BW, ethyl acetate fraction group dose of 34,44 mg/Kg BW of and n-hexane fraction group dose of 80,74 mg/Kg BW. All groups were induced by STZ-NA (45/110 mg/Kg BW), except for the normal group. Blood glucose level examination was carried out for 28 days, then it was seen a decrease in blood glucose levels and improvement of pancreatic β cells. The results showed that all extract groups and oyong seed fractions had activities in reducing blood glucose levels in STZ-NA induced DM rats. Ethyl acetate fraction is the best test fraction for lowering blood glucose levels and have better cell regeneration compared to n-hexane fraction, water fraction or oyong seed extract. Keywords : antihyperglycemia, diabetes mellitus, oyong seeds, STZ-NA

Item Type: Thesis (Tesis)
Uncontrolled Keywords: antihyperglycemia, diabetes mellitus, oyong seeds, STZ-NA
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Mrs NOVI HANDAYANI
Date Deposited: 01 Nov 2019 07:30
Last Modified: 01 Nov 2019 07:30
URI: http://repository.setiabudi.ac.id/id/eprint/3447

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