PENGARUH PENINGKATAN KADAR HDL DAN PENURUNAN KADAR LDL SETELAH PEMBERIAN EKSTRAK ETANOL KULIT MANGGIS (Garcinia mangostana L.) DAN α MANGOSTEN PADA TIKUS HIPERGLIKEMIK

Dharmayanti, Luky (2019) PENGARUH PENINGKATAN KADAR HDL DAN PENURUNAN KADAR LDL SETELAH PEMBERIAN EKSTRAK ETANOL KULIT MANGGIS (Garcinia mangostana L.) DAN α MANGOSTEN PADA TIKUS HIPERGLIKEMIK. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

The mangosteen rind (Garcinia mangostana L.) contains various secondary metabolite contents collectively called mangostin which shows certain biological activities as a source of antioxidants. Diabetes mellitus will cause carbohydrate and fat metabolism to be disrupted, Disorders of insulin secretion occur because of the presence of free radicals due to STZ induction which can increase reactive oxygen which has a high role in pancreatic β cell damage. This study aims to determine the effect of mangosteen peel extract and alpha mangosten isolates on blood sugar levels, HDL levels, and LDL in STZNA-induced mice. This study used 60 male white wistar rats, divided randomly into twelve treatment groups, namely normal control, negative control, positive control each for extracts and isolates, EKBM dose 25, 50, 100 mg / kg bw and isolates α mangosten dose 0.032, 0.064, 0.13 mg / kg bw. STZ-NA administration on day 0, measured glucose level 3 days after hyperglycemic occurred and then treated with test preparation for 28 days. Parameters measured were blood glucose levels using the GOD PAP method, HDL levels, and LDL levels with the CHOD PAP method. Data on HDL and LDL levels were analyzed by normality test then followed by statistical tests of kruskall wallis asymo sig 2 tailed (p) <0.05 and continued Witney Test asymo with 2 tailed (p)> 0.05. The results showed that the administration of EKBM dose 25, 50,100 mg / kg bw and alpha mangosten isolates 0.032, 0.064, 0.13 mg / kg bw for 28 days were able to reduce blood glucose levels, LDL levels and increase HDL levels significantly (p <0.05 ). Keywords: Garcinia mangostana.L, Diabetes mellitus, STZ-NA, Blood sugar, HDL, LDL

Item Type: Thesis (Tesis)
Uncontrolled Keywords: Garcinia mangostana.L, Diabetes mellitus, STZ-NA, Blood sugar, HDL, LDL
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Mrs NOVI HANDAYANI
Date Deposited: 01 Nov 2019 07:30
Last Modified: 01 Nov 2019 07:30
URI: http://repository.setiabudi.ac.id/id/eprint/3439

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