UJI AKTIVITAS ANTIHIPERGLIKEMI DAN REGENERASI SEL β PANKREAS EKSTRAK DAN FRAKSI–FRAKSI EKSTRAK BUAH OKRA (Abelmoschus esculenta (L) Moench) PADA TIKUS YANG DIINDUKSI STREPTOZOTOSIN-NIKOTINAMIDA

Herdianty, Juvita (2019) UJI AKTIVITAS ANTIHIPERGLIKEMI DAN REGENERASI SEL β PANKREAS EKSTRAK DAN FRAKSI–FRAKSI EKSTRAK BUAH OKRA (Abelmoschus esculenta (L) Moench) PADA TIKUS YANG DIINDUKSI STREPTOZOTOSIN-NIKOTINAMIDA. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Diabetes mellitus (DM) is a disease caused by metabolic disorders resulting in increased blood sugar levels. Problems arising out of the current existence of the side effects of oral antihiperglikemi drug use. The goal of the research is to know the antihiperglikemi and regeneration of pancreatic cells from ethanol extracts and fractions-fraction of the okra. This study used seven groups of rats and streptozotocin-nicotinamid induced 45/110 mg, except group 1 was normal control group. Group 2 was given a CMC-Na 0,5%, group 3 was given of Glicazide, group 4 was given a okra fruit extract 200 mg/kg, group 5 was given n-hexane fraction 107 mg/kg, group 6 was given ethyl acetate fraction 6 mg/kg and group 7 was given water fraction 86mg/kg. Test material was administered orally for 28 days, then seen an increase in body weight of rats, a decrease in blood glucose levels, and improvement of pancreatic histopathology profile with Hemaktosilin-eosin. The results showed that ethyl acetate fraction decrease in blood glucose levels and pancreatic regeneration. Ethyl acetate fraction most active fraction to other fractions group with a value of anti-hyperglycemic activity of 44,95%. Keywords: Abelmoschus esculentus, fractions, diabetes mellitus, streptozotocinnicotamide, blood glucose level.

Item Type: Thesis (Tesis)
Uncontrolled Keywords: Abelmoschus esculentus, fractions, diabetes mellitus, streptozotocinnicotamide, blood glucose level.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Mrs NOVI HANDAYANI
Date Deposited: 01 Nov 2019 07:33
Last Modified: 01 Nov 2019 07:33
URI: http://repository.setiabudi.ac.id/id/eprint/3431

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