PEL (Stelechocarpus burahol NEKROSIS HATI TIKUS JANTAN GALUR WISTAR YANG DIINDUKSI PARASETAMOL AKTIVITAS FRAKSI ETANOLIK EKSTRAK AIR DAUN KEPEL (Stelechocarpus burahol (BI.) Hook f. & Th.) TERHADAP NEKROSIS HATI TIKUS JANTAN GALUR WISTAR YANG DIINDUKSI PARASETAMOL

Riandini, Tantri (2013) PEL (Stelechocarpus burahol NEKROSIS HATI TIKUS JANTAN GALUR WISTAR YANG DIINDUKSI PARASETAMOL AKTIVITAS FRAKSI ETANOLIK EKSTRAK AIR DAUN KEPEL (Stelechocarpus burahol (BI.) Hook f. & Th.) TERHADAP NEKROSIS HATI TIKUS JANTAN GALUR WISTAR YANG DIINDUKSI PARASETAMOL. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Kepel leaves has been investigated as an antioxidant. This study aims to determine the ability of ethanolic fraction of leaf kepel water extract against liver of white male Wistar rats after induced by paracetamol in reducing the percentage of necrosis of liver cells under negative control. This research using thirty rats were divided into 6 groups. Group I: normal controls who were given only fed and watered. Group II: negative controls were given only paracetamol, Group III: positive controls were given Curcuma® tablet with dose 7, 2 mg/200 g BW. Group IV, V, and VI as the treatment group were given ethanolic fraction with dose 6 mg/200 g BW, 12 mg/200 g BW, and 18 mg/200 g BW. Treatment was for 7 days. On fifth day, all groups except normal controls, were given single dose of 2.5 g paracetamol / kg BW together with the provision of treatment fraction. On seventh day of test animals were sacrificed to take his heart made preparations for histology. The data obtained were analyzed by One Way ANOVA (p <0,05) followed Tukey HSD test. The results showed a significant difference between treatment groups fraction dose of 6 mg, 12 mg, and 18 mg/200 g BW with a negative control (p <0.05), the percentage of necrosis was 38.58%, 29.01% and 17 , 42%. On the dose of 18 mg/200 g fraction BW percentage of necrosis was no significant difference in the positive control it was shown that the ethanolic fraction dose of 18 mg/200 g BW has hepatoprotective capability similar to Curcuma after induced by paracetamol. Key word : ethanolic fraction, kepel leaves, paracetamol, nekrosis

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: ethanolic fraction, kepel leaves, paracetamol, nekrosis
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: B Supri Yadi
Date Deposited: 16 Nov 2019 04:13
Last Modified: 16 Nov 2019 04:13
URI: http://repository.setiabudi.ac.id/id/eprint/3062

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