EFEK ANTIDIABETES KOMBINASI INFUS HERBA KEMANGIGLIBENKLAMID DAN KOMBINASI INFUS HERBA KEMANGIMETFORMIN PADA MENCIT DENGAN METODE INDUKSI ALOKSAN

Kumalasari, Sri Hardiyati (2013) EFEK ANTIDIABETES KOMBINASI INFUS HERBA KEMANGIGLIBENKLAMID DAN KOMBINASI INFUS HERBA KEMANGIMETFORMIN PADA MENCIT DENGAN METODE INDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Plant basil (Ocimum basilicum L.) is a plant that has been known to be able to alternative antidiabetic drugs. One of cause of DM is destroy pancreatic β cells. This study aimed to determine the effect and the most effective dose for the combination of basil-herb infusion and intravenous glibenclamide-metformin herb basil can give the effect of decreasing blood glucose levels in male mice in induced alloxan. The research was conducted with a random design using white male mice, strain Balb/c, age 3-4 months, weight 15-30 grams. All the mice were made diabetic using alloxan intraperitonial. Mice were divided into 10 groups, each group consisted of 8 mice. Group I: negative control, group II: glibenclamide, group III: metformin, group IV infusion herbaceous basil, 3 group basil herbinfused combination of glibenclamide and 3 group basil herb-infused combination of metformin. Glucose level be measure on day 4 and 8, with Easy-Touch glukotest. The results of blood sugar levels were analyzed by one way ANOVA (p<0.05). The results showed a combination of intravenous administration of basil herb-glibenclamide (0,25:0,75; 0,5:0,5; 0,75:0,25) can lower blood glucose levels comparable to the effects of glibenklamid (p <0.05). The combination of basilinfused herbal metformin (0,25:0,75 and 0,5:0,5) can lower blood glucose levels as well as metfromin (p<0.05). Keywords: Ocimum basilicum L., alloxan, blood glucose, glibenclamide, metformin.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Ocimum basilicum L., alloxan, blood glucose, glibenclamide, metformin.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: B Supri Yadi
Date Deposited: 22 Nov 2019 03:52
Last Modified: 22 Nov 2019 03:52
URI: http://repository.setiabudi.ac.id/id/eprint/3056

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