OPTIMASI TABLET SUSTAINED RELEASE SALBUTAMOL SULFAT DENGAN MATRIKS NATRIUM KARBOKSIMETILSELULOSA DAN HIDROKSIPROPIL METILSELULOSA DENGAN METODE SIMPLEX LATTICE DESAIN

Apriliana, Endang Wahyu (2013) OPTIMASI TABLET SUSTAINED RELEASE SALBUTAMOL SULFAT DENGAN MATRIKS NATRIUM KARBOKSIMETILSELULOSA DAN HIDROKSIPROPIL METILSELULOSA DENGAN METODE SIMPLEX LATTICE DESAIN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Salbutamol Sulphate is a beta-2 agonist adrenergic that is widely used in the treatment of asthma and obstructive pulmonary disease. Salbutamol Sulphate is a short acting bronchodilators which have short biological half life about 2,7h and the usage is 2mg-4mg, administered orally three to four times a day. Based on that, study is concerned on the manufacture of salbutamol sulphate tablets using HPMC and Na-CMC matrix. Sustained release formulation is expected to produce in the concentration of drug in the blood that is more uniform and the peak levels do not fluctuate. This study was based on the method simplex lattice design (SLD) with two matrix components, they were HPMC and Na-CMC. The research was made in three formulas are: FI(100% HPMC), FII(50% HPMC: 50% N-a-CMC), FIII(100% Na-CMC). The tablets were made by wet granulation. Then obtained granules and tablets were tested their physical quality. The parameters used for SLD equation was flow rate, absorption, compactibility, and dissolution. Then calculated the response using design expert 8.0.6.1 to determine the optimum formula. The results of theoretical and experimental optimum formula were analyzed using t-test. The results showed that salbutamol sulfat sustained release could be made to be sustained release preparation and the combination of HPMC and Na-CMC matrix affected the physical quality and the release of salbutamol sulfat tablet. The proportion that produced sustained release salbutamol sulfat tablet with a maximum physical quality was the formula containing HPMC 77,2% dan NaCMC 22,8%. Keywords : Salbutamol sulfat, sustained release, HPMC, MC

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Salbutamol sulfat, sustained release, HPMC, MC
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: magdalena kartika ningsih
Date Deposited: 20 Nov 2019 04:24
Last Modified: 20 Nov 2019 04:24
URI: http://repository.setiabudi.ac.id/id/eprint/2982

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