OPTIMASI CO-PROCESSED EXCIPIENT CAMPURAN MANITOL DAN AVICEL PH 101 SEBAGAI BAHAN PENGISI-PENGIKAT TABLET KEMPA LANGSUNG SECARA Simplex Lattice Design

Kurniawati, Erna (2013) OPTIMASI CO-PROCESSED EXCIPIENT CAMPURAN MANITOL DAN AVICEL PH 101 SEBAGAI BAHAN PENGISI-PENGIKAT TABLET KEMPA LANGSUNG SECARA Simplex Lattice Design. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

method that has cost and time efficient, but require a filler-binder properties that has good flowability and compactibility. The filler-binder material was obtained from co-processing mannitol and Avicel PH 101 by spray drying to get the co-processed excipient with good flowability and good compactibility. Optimum formula of co-processed excipient was obtained by simplex lattice design approach. The co-processed excipient was made from a mixture of mannitol and Avicel PH 101 by spray drying with a concentration of 20 %. Optimization was made by simplex lattice design in five formulas with the composition of 100 % mannitol, 75 % mannitol : 25 % Avicel PH 101, 50 % mannitol : 50 % Avicel PH 101, 25 % mannitol : 75 % Avicel PH 101, and 100 % Avicel PH 101. Evaluation of the physical characteristics of the co-processed excipient included moisture content, viscosity, flow rate and angle of repose, compactibility, bulk and tapped density, Carr's index, and melting point. Evaluation of tablet properties included uniformity of size and weight, hardness, friability, disintegration time and dissolution testing of tablets. Determination of the optimum formula was based on the physical characteristics of the co-processed excipient and the tablet properties parameters, used Design Expert version 8.0.7.1®. Optimum formula of co-processed excipient was at the composition of 38,93 % mannitol and 61,07 % Avicel PH 101. Keywords : co-processed excipient, spray drying, manitol, Avicel PH 101, simplex lattice design

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: co-processed excipient, spray drying, manitol, Avicel PH 101, simplex lattice design
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: magdalena kartika ningsih
Date Deposited: 20 Nov 2019 04:23
Last Modified: 20 Nov 2019 04:23
URI: http://repository.setiabudi.ac.id/id/eprint/2980

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