UJI EFEK HIPOGLIKEMIK EKSTRAK ETANOL AKAR ILER (Coleus scutellarioides Rdx.) PADA TIKUS PUTIH JANTAN GALUR WISTAR DENGAN INDUKSI ALOKSAN

Lovianie, Mensie Martha (2013) UJI EFEK HIPOGLIKEMIK EKSTRAK ETANOL AKAR ILER (Coleus scutellarioides Rdx.) PADA TIKUS PUTIH JANTAN GALUR WISTAR DENGAN INDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Diabetes mellitus is a disease that affects many people today. Iler radix (Coleus scutellarioides Rdx.) leaves is a traditional medicinal plant contains saponins, flavonoids, tannins which one of the benefits to treat diabetes mellitus. This study aims to determine the hypoglycemic effect of ethanol extract of iler radix (Coleus scutellarioides Rdx.) and seek the most effective dose to decrease blood glucose levels in Wistar male rats. The methods that were used was alloxan test methods. Rats were divided into five treatment groups where each group consisted of five rats. Group I as a negative control (CMC 0,5%). Group II,III,IV, given doses of ethanol extract of Iler radix (Coleus scutellarioides Rdx.) row rats 38,5 mg/200 g BB, 77 mg/200 g BB, 154 mg/200 g BB rats, and group V as a positive control (glibenclamied) at dose of 0,09 mg/200 g BB rats. All group alloxan induced on day 0 (after fasting 16 hours) intraperitoneally. Examination of blood sugar levels performed on days 4 and 8 after administration of the test preparation. Form the result of statistical tests had results that the ethanol extract of the roots of radix iler with doses 38,5 mg/200 g BB, 77 mg/200 g BB, 154 mg/200 g BB rats don’t give a significant difference in hypoglycemic effect. Statistical analysis of the results of the ethanol extract of radix iler 38,5 mg/200 g BB, 77 mg/200 g BB, 154 mg/200 g BB rats no difference of meaning so that the smallest dose of 38,5 mg/200 g BB rats have hypoglycemic effects in male rats anduced alloxan. Keywords : radix iler, alloxan, hypoglycemic

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: radix iler, alloxan, hypoglycemic
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: B Supri Yadi
Date Deposited: 20 Nov 2019 04:21
Last Modified: 20 Nov 2019 04:21
URI: http://repository.setiabudi.ac.id/id/eprint/2977

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