OPTIMASI FORMULASI ORALLY DISINTEGRATING TABLET IBUPROFEN DENGAN KOMBINASI PENGISI MANITOL DAN PENGHANCUR AC-DI-SOL® DENGAN METODE SIMPLEX LATTICE DESIGN

Widyastuti, Yuli (2014) OPTIMASI FORMULASI ORALLY DISINTEGRATING TABLET IBUPROFEN DENGAN KOMBINASI PENGISI MANITOL DAN PENGHANCUR AC-DI-SOL® DENGAN METODE SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Ibuprofen is one of nonsteroid antiinflammatory drug, it has pharmacological action as an analgesic, antipyretic and antiinflamatory that widely used in society. Ibuprofen in conventional dosage form causes disobedience of pediatric and geriatric in the use of the drug, due to difficulty swallowing. Therefore, ibuprofen is suitable to be made in Orally Disintegrating Tablet. Accordingly, a study was conducted on the manufacture of Orally Disintegrating tablets of ibuprofen using mannitol as excipients and Ac-Di-Sol® as disintegrant. The study was done by simplex lattice design method (SLD) with mannitol components (A) and Ac-Di-Sol®(B), to obtain 3 draft formula that were 100% A : 0% B (FI), 50% A : 50% B (FII ), 0%A : 100% B (FIII), that were made by dry granulation. Flowing time, water absorption, disintegrating time, and dissolution optimization parameters. Based on a SLD model obtained the equation of each parameter, so it can be determined the optimum formula. The results of theoritical and experimental of optimum formula were analyzed using t-test. Combination of mannitol and Ac-Di-Sol® affected on the physical properties ODT of ibuprofen. Based on data from simplex lattice design, ratio of 79.31% mannitol and 20.69% Ac-Di-Sol® was the optimum formula that could produce Orally Disintegrating Tablet of ibuprofen with physical properties that fulfilled the requirements and provide good taste. Keywords : Ibuprofen, Orally Disintegrating Tablet, Mannitol, Ac-Di-Sol®

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Ibuprofen, Orally Disintegrating Tablet, Mannitol, Ac-Di-Sol®
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 20 Nov 2019 04:53
Last Modified: 20 Nov 2019 04:53
URI: http://repository.setiabudi.ac.id/id/eprint/2914

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