OPTIMASI PROPORSI KOMBINASI MATRIKS HIDROKSIPROPIL METILSELULOSA K15M DAN XANTHAN GUM PADA TABLET LEPAS LAMBAT KAPTOPRIL DENGAN METODE SIMPLEX LATTICE DESIGN

Imannia, Runi (2014) OPTIMASI PROPORSI KOMBINASI MATRIKS HIDROKSIPROPIL METILSELULOSA K15M DAN XANTHAN GUM PADA TABLET LEPAS LAMBAT KAPTOPRIL DENGAN METODE SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Captopril as an inhibitor of angiotensin converting enzyme (ACE) for heart failure and hypertension treatment. Captopril as water soluble drug, has a half-life of 2-3 hours, the daily dose 12.5-25 mg two to three times, the maximum dose of 150 mg a day, and suitable for sustained release dosage form. This study aimed to determine the effect of the combination of HPMC K15M and xanthan gum as matrix in captopril sustained release tablets of on the physical properties of the granules and dissolution profiles. In addition, this study aimed to finding out the optimum proportion of matrix combination of HPMC K15M and xanthan gum in captopril sustained release tablets. Tablets were made by wet granulation method. Comparison matrix of HPMC K15M (A) and xanthan gum (B) present in the formula 5, there are : 100 % (A) (F1), 75 % (A) : 25 % (B) (F2), 50 % (A) : 50 % (B) (F3), 25 % (A) : 75 % (B) (F4), 100 % (B) (F5). Dissolution test was performed in 0.1 N HCl medium at 37  0.5C with a speed of 50 rpm for 6 hours using a paddle. Flow time, friability, Q60, Q360 and dissolution efficiency (DE360) were computed with software Design Expert 8.0.6.1. The results showed that the combination of HPMC K15M and xanthan gum as matrix affected the physical properties of granules, tablets and drug release. The interaction of HPMC K15M and xanthan gum reduced friability, reduced Q60,increase Q360 and increase DE360. HPMC K15M and xanthan gum has not significant interaction in flow time. The optimum formula 25,47% A dan 74,53% B. Keywords : captopril , HPMC K15M , xanthan gum , sustained release tablets.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: captopril , HPMC K15M , xanthan gum , sustained release tablets.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 20 Feb 2020 02:29
Last Modified: 20 Feb 2020 02:29
URI: http://repository.setiabudi.ac.id/id/eprint/2784

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