OPTIMASI FORMULASI ORALLY DISINTEGRATING TABLET IBUPROFEN DENGAN KOMBINASI PENGHANCUR AC-DI-SOL DAN PENGIKAT MICROCRYSTALLINE CELLULOSE DENGAN METODE SIMPLEX LATTICE DESIGN

Muliawati, Nisa’ul Budi (2014) OPTIMASI FORMULASI ORALLY DISINTEGRATING TABLET IBUPROFEN DENGAN KOMBINASI PENGHANCUR AC-DI-SOL DAN PENGIKAT MICROCRYSTALLINE CELLULOSE DENGAN METODE SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Ibuprofen is analgesic drug that can relieve mild to moderate pain. To improve the convenience and compliance of patient in taking medication especially pediatric and geriatric patients, the dosage of ibuprofen is made in Orally Disintegrating Tablet. It is designed to immediately disintegrate in the mouth with the help of little water for fast drug release. According to this, a study was conducted on the optimization of Orally Disintegrating Tablet ibuprofen with a combination of disintegrating Ac-di-sol® and binder microcystalline cellulose. The study was made in three formulas, they were : FI (microcystalline cellulose 100% : Ac-di-sol® 0%), FII (microcystalline cellulose 50% : Ac-di-sol® 50%) and F III (microcystalline cellulose 0% : Ac-di-sol® 100%). Tablets were made by dry granulation method, and compressed to 205 mg weight of tablet and tested for the physical properties. The properties determinations of the optimum formula used Simplex Lattice Design method(SLD) wih Software Design Expert 8.0.6.The experimenal results and the theoritical optimum formula were analyzed using t-test. The result showed that ibuprofen could be made orally disintegrating tablet preparation, and the combination of disintegrating Ac-di-sol® and binder microcystalline cellulose affected the phisical quality of tablet with the proportion microcystalline cellulose 90% dan Ac-di-sol® 10%. Key words: ibuprofen, orally disintegrating tablet, SLD, microcystalline cellulose, Ac-di-sol®

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: ibuprofen, orally disintegrating tablet, SLD, microcystalline cellulose, Ac-di-sol®
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 19 Feb 2020 07:48
Last Modified: 19 Feb 2020 07:48
URI: http://repository.setiabudi.ac.id/id/eprint/2652

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