UJI AKTIVITAS DIURETIK EKSTRAK ETANOL DAUN PUTRI MALU ( Mimosa pudica L .) DAN DAUN ALPUKAT ( Persea americana, Mill) PADA TIKUS PUTIH JANTAN GALUR WISTAR

Putro, Ganzar Kristiandi Setyo (2014) UJI AKTIVITAS DIURETIK EKSTRAK ETANOL DAUN PUTRI MALU ( Mimosa pudica L .) DAN DAUN ALPUKAT ( Persea americana, Mill) PADA TIKUS PUTIH JANTAN GALUR WISTAR. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Putri malu (Mimosa pudica L.) and avocado (Persea americana Mill.) leaves can be used as diuretic agent. This research aimed to find out the diuretic effect of combined putri malu and avocado leaves ethanol extract on Wistar male rat. The tested animal used consisted of 35 rats, divided into 7 treatment groups: furosemida positive control (1.44 mg/200 g BW), negative control CMC 0.5%, single extract of putri malu leaf (20 mg/200 g BW), single extract of avocado leaf (20 mg/200 g BW), combination of putri malu and avocado leaves ethanol extract (½ : ½) (10 mg/200 g BW : 10 mg/200 g BW), putri malu and avocado leaves ethanol extract (¼ : ¾) (5 mg/200 g BW : 15 mg/200 g BW), putri malu and avocado leaves ethanol extract (¾ : ¼) (15 mg/200 g BW : 5 mg/200 g BW). Urine was contained in metric glasses, observation was conducted every hour for 6 hours, and then at 12 and 24 hours. The diuretic effect was obtained by estimating cumulative urine volume and AUC (Area Under The Curve). The data was processed using one-way variance analysis followed by Tukey HSD test. The result of research the combination of putri malu and pacar kuku leaves ethanol extract had diuretic effect higher than the single extract. The combination of putri malu (Mimosa pudica L) and avocado (Persea americana ,Mill) leaves ethanol extract with (½ : ½) (10 mg/200 g rat BW : 10 mg/200 g rat BW) ratio could provide the most optimum diuretic effect. Keywords: Putri malu (Mimosa pudica L.), Avocado (Persea americana Mill.), ethanol extract, Diuretic, Furosemida

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Putri malu (Mimosa pudica L.), Avocado (Persea americana Mill.), ethanol extract, Diuretic, Furosemida
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 19 Feb 2020 06:23
Last Modified: 19 Feb 2020 06:23
URI: http://repository.setiabudi.ac.id/id/eprint/2432

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