FORMULASI TABLET MUKOADHESIF PROPRANOLOL HCl DENGAN KOMBINASI MATRIKS XANTHAN GUM DAN HPMC K15M

Rahman, Fauzi (2014) FORMULASI TABLET MUKOADHESIF PROPRANOLOL HCl DENGAN KOMBINASI MATRIKS XANTHAN GUM DAN HPMC K15M. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Propranolol HCl is a beta-blocker class of drugs for treatment of hypertension that has characteristics ofa a water-soluble, tha half time of 3-6 hours and almost complete absorbed in the gastrointestinal. Formulations of propranolol HCl in sustained release mucoadhesive system can maintain drug level at therapeutic concentrations in a longer time. This study aims to determine the xanthan gum dan HPMC K15M can influence the physical properties of tablets and dissoluiton profile. The research was conducted on the five comparison matrix formula with xanthan gum and HPMC K15M differently in FI (100% : 0%), FII (75% : 25%), FIII (50% : 50%), FIV (25% : 75%) and FV (0% : 100%). The weight each tablet was containing250 mg of propranolol HCl 80 mg. Each formula was tested the physical properties of the granules (flow time, moisture, water absorption), the physical properties of tablets (weight uniformity, hardness, friability, swelling index, mucoadhesive adhesion) and dissolution test. Data were analyzed by statistical test using one way ANOVA. The results showed that the increased in xanthan gum could reduce flow time, moisture,water absorption and increased the swelling index, mucoadhesive adhesion and drug release rate. Formula I with ratio of 100% xanthan gum and 0% HPMC K15M was the best fomula because it hadgood physical quality and concentration level approaching dissolution therapeutic of propranolol HCl. Key words : Propranolol HCl, Xanthan gum, HPMC K15M, Mucoadhesive

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Propranolol HCl, Xanthan gum, HPMC K15M, Mucoadhesive
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 19 Feb 2020 06:21
Last Modified: 19 Feb 2020 06:21
URI: http://repository.setiabudi.ac.id/id/eprint/2425

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