UJI AKTIVITAS DIURETIK EKSTRAK ETANOL KOMBINASI DAUN PUTRI MALU (Mimosa pudica L.) DAN DAUN PACAR KUKU (Lawsonia inermis L.) PADA TIKUS JANTAN GALUR WISTAR

Sari, Dwi Novita Eka (2014) UJI AKTIVITAS DIURETIK EKSTRAK ETANOL KOMBINASI DAUN PUTRI MALU (Mimosa pudica L.) DAN DAUN PACAR KUKU (Lawsonia inermis L.) PADA TIKUS JANTAN GALUR WISTAR. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Putri malu (Mimosa pudica L.) and pacar kuku (Laswonia inermis L.) leaves can be used as diuretic agent. This research aimed to find out the diuretic effect of combined putri malu and pacar kuku leaves ethanol extract as the effective dose on Wistar male rat. The tested animal used consisted of 35 rats, divided into 7 treatment groups: furosemida positive control (1.44 mg/200 g BW), negative control CMC 0.5%, single extract of putri malu leaf (20 mg/200 g BW), single extract of pacar kuku leaf (50 mg/200 g BW), combination of putri malu and pacar kuku leaves ethanol extract (½ : ½) (10 mg/200 g BW : 25 mg/200 g BW), putri malu and pacar kuku leaves ethanol extract (¼ : ¾) (5 mg/200 g BW : 37.5 mg/200 g BW), putri malu and pacar kuku leaves ethanol extract (¾ : ¼) (15 mg/200 g BW : 12.5 mg/200 g BW). Urine was contained in gelas ukur, observation was conducted every hour for 6 hours, and then at 12 and 24 hours. The diuretic effect was obtained by estimating cumulative urine volume and AUC (Area Under The Curve). The data was processed using one-way variance analysis followed by Tukey HSD test. The result of research the combination of putri malu and pacar kuku leaves ethanol extract has a diuretic effect. The extract combination had diuretic effect higher than the single extract. The combination of putri malu and pacar kuku leaves ethanol extract with (¼ : ¾) and (¾ : ¼) ratio have activity compatible to the positive control. Keywords: Putri malu, Pacar kuku, Combination, Diuretic.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Putri malu, Pacar kuku, Combination, Diuretic.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 18 Feb 2020 06:21
Last Modified: 18 Feb 2020 06:21
URI: http://repository.setiabudi.ac.id/id/eprint/2312

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