UJI AKTIVITAS HIPOGLIKEMIK KOMBINASI EKSTRAK DAUN CEPLIKAN (Ruellia tuberosa L.) DAN GLIBENKLAMID PADA TIKUS PUTIH JANTAN DENGAN INDUKSI ALOKSAN

Yuniasakti, Bunga (2014) UJI AKTIVITAS HIPOGLIKEMIK KOMBINASI EKSTRAK DAUN CEPLIKAN (Ruellia tuberosa L.) DAN GLIBENKLAMID PADA TIKUS PUTIH JANTAN DENGAN INDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.

[img] Text
BAB II.pdf
Restricted to Repository staff only

Download (270kB) | Request a copy
[img] Text
BAB III.pdf
Restricted to Repository staff only

Download (126kB) | Request a copy
[img] Text
BAB IV.pdf
Restricted to Repository staff only

Download (370kB) | Request a copy
[img] Text
BAB V-LAMPIRAN.pdf

Download (2MB)
[img] Text
COVER-BAB I.pdf

Download (622kB)
[img] Text
INTISARI.pdf

Download (88kB)

Abstract

Diabetes mellitus is a disease or metabolic disorder characterized with high blood glucose level accompanied with carbohydrate, lipid and protein metabolism disorder as a result of insufficient insulin function. In this study, ceplikan (Ruellia tuberossa L.) leaves contained flavonoid, saponin, and tannin with hypoglycemic activity. This research aimed to find out the hypoglycemic effect of ceplikan leaf extract and glibencamide combination, the effective dose of such combination, and to find out the comparison of hypoglicemic effect between single extract and combination use. The extract of ceplikan leaves was obtained using maceration method with ethanol 70% solvent. The diabetic condition of animal was obtained using monohidrate alloxane induction 100 mg/kg BW. The treatment groups were divided into 6: negative control group with CMC, positive control with glibenclamide (0.09 mg/200 g BW rat), single dose of ceplikan leaves extract (187.5 g rat BW), combination of glibenclamide and ceplikan leaves extract (0.25:0.75; 0.50:0.50; 0.75:0.25). The blood glucose level was measured using glucometer on the day-7, and -14. The result of research showed that the combination of glibenclamide and ceplikan leaves extract had hypoglycemic activity. The effective doses of glibenclamide and ceplikan leaves extract combination were 0.50:0.50; 0.75:0.25. The glibenclamid-extract combination had hypoglycemic effect lower than the single extract did. Keywords: Ruellia tuberossa L., Glibenclamid, monohydrate alloxane, hypoglycemic

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Ruellia tuberossa L., Glibenclamid, monohydrate alloxane, hypoglycemic
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 18 Feb 2020 04:09
Last Modified: 18 Feb 2020 04:09
URI: http://repository.setiabudi.ac.id/id/eprint/2289

Actions (login required)

View Item View Item