PENGARUH METIL SELULOSA 4000 DAN PROPILEN GLIKOL TERHADAP STABILITAS FISIK DAN AKTIVITAS ANTIOKSIDAN GEL VITAMIN C

Nilawati, Anita (2015) PENGARUH METIL SELULOSA 4000 DAN PROPILEN GLIKOL TERHADAP STABILITAS FISIK DAN AKTIVITAS ANTIOKSIDAN GEL VITAMIN C. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Vitamin C is one of antioxidant and it’s usefull to prevent skin from UV damage. Vitamin C gel is preferably because it is not sticky, easy to spread, and not leaving oily texture on skin. Methyl cellulose 4000 can influence viscosity and propylene glycol is a cosolvent with dielectrict constant lower than water, this 2 factors can increase the stability of vitamin C gel. This study aimed to optimize and evaluate the influence of methyl cellulose 4000 and propylene glycol to physical stability and antioxidant activity of vitamin C gel. A 22 factorial design was applied to optimize the vitamin C gel using methyl cellulose 4000 and propylene glycol as independent variables. Each factor had 2 levels i.e 2% and 3% for methyl cellulose 4000, 10% and 20% for propylene glycol. The optimum area was determined by superimposed contour plot of viscosity, spreadability, stickability, viscosity changes, assays, and antioxidant activity using Design Expert software. The results showed that methyl cellulose 4000 and propylene glycol influence the physical stability and antioxidant activity of vitamin C gel. Increasing concentration methyl cellulose 4000 had increase the viscosity, stickability, assays and antioxidant activity and at the other hand decrease spreadability, and viscosity changes. Increasing propylene glycol concentration had increase viscosity while interaction between methyl cellulose 4000 and propylene glycol increasing antioxidant activity. Optimum formula of vitamin C gel was on 2.71% of methyl cellulose 4000 and 15.15% of propylene glycol. The optimum formula has stable physical and antioxidant activity for 28 days. Key words: methyl celllulose 4000, propylene glycol, vitamin C gel, physical stability and antioxidant activity

Item Type: Thesis (Tesis)
Uncontrolled Keywords: methyl celllulose 4000, propylene glycol, vitamin C gel, physical stability and antioxidant activity
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: magdalena kartika ningsih
Date Deposited: 22 Nov 2019 09:23
Last Modified: 22 Nov 2019 09:23
URI: http://repository.setiabudi.ac.id/id/eprint/2266

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