FORMULASI DAN OPTIMASI SEDIAAN TABLET BUKAL BILAYER SIMVASTATIN DENGAN POLIMER CARBOPOL 934P, HPMC DAN ENHANCER POLIETILEN GLIKOL (PEG 6000)

Putri, Aristha Novyra (2015) FORMULASI DAN OPTIMASI SEDIAAN TABLET BUKAL BILAYER SIMVASTATIN DENGAN POLIMER CARBOPOL 934P, HPMC DAN ENHANCER POLIETILEN GLIKOL (PEG 6000). Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Simvastatin have the ability to reduce Low-Density Lipoprotein Cholesterol and increase High Density Lipoprotein Cholestrol. Simvastatin has low bioavailability caused by high first-pass metabolism effect, and short biological half-life (3 jam) The purpose of this research was to prepare the mucoadhesive bilayered tablet of simvastatin by using mucoadhesive polymers such as Carbopol, Hydroxy propyl methyl cellulose (HPMC) in different concentration and to determine the influence of count variation of polymer on the physical properties and drug release, as well as assess the ability of simvastatin permeation on the optimized formulation. The determination of formulas with 23 design factorial using Design Expert Software® as 8 formulas. Tablets were prepared by direct compression method. The first layer which adheres to mucosa and containing of mucoadhesive polymers and drug. The second layer as backing membran and contain water impermeable agent. Tablets were subjected for physicochemical characterization test such as weight, weight variation, dimensions, thickness, hardness, swelling index, time and mucoadhesive strength, drug content, in vitro drug release study, surface pH, and stability in saliva simulation. Optimized buccal mucoadhesive bilayered tablet formulation were subjected for in vitro drug permeation through sheep buccal mucosa on 8 hour. The test results showed that Carbopol and PEG 6000 significantly increase the swelling index and strength adhesions, while the HPMC significantly lower the swelling index and strength adhesion. PEG 6000 significantly increases drug release, while Carbopol and HPMC significantly lowering of drug release. In vitro drug permeation was found 22,02±0,14% in 8h, lag time 0,05h, fluks 0,068 µg.cm-2.hour-1, and diffusion coefficient 7,5 cm2.jam-1. Mucoadhesive polymers Carbopol, HPMC, and PEG 6000 in various proportions can be used to prepare buccal mucoadhesive bilayered tablet of simvastatin. Key: simvastatin, buccal bilayer, Carbopol, HPMC, permeation

Item Type: Thesis (Tesis)
Uncontrolled Keywords: simvastatin, buccal bilayer, Carbopol, HPMC, permeation
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 14 Oct 2019 04:41
Last Modified: 14 Oct 2019 04:41
URI: http://repository.setiabudi.ac.id/id/eprint/2035

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