FORMULASI DAN OPTIMASI SEDIAAN PATCH BUKAL MUKOADHESIF SIMVASTATIN DENGAN POLIMER CARBOPOL 934P, HPMC DAN ENHANCER PROPILENGLIKOL

Ningsih, Ade Irma Fitria (2015) FORMULASI DAN OPTIMASI SEDIAAN PATCH BUKAL MUKOADHESIF SIMVASTATIN DENGAN POLIMER CARBOPOL 934P, HPMC DAN ENHANCER PROPILENGLIKOL. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Simvastatin is an oral drug used to lower cholesterol or hypercholesterolemia. Simvastatin has short biological half-life (2-3 hr), high first-pass metabolism and poor oral bioavailability (5%). One effort to overcome the weaknesses of simvastatin is to make in dosage forms mucoadhesive buccal patches, buccal patches reason preparations made for more flexible. Carbopol 934P polymer functions to control the release of drug, HPMC is used to control the release of active substances in the oral cavity, propilenglikol used as an enhancer for having conduction paracelullar with these mechanisms of action may increase drug absorption without damaging the buccal membrane. The purpose of this study was to determine the effect of variations in the amount of carbopol 934P, HPMC as the polymer and propilenglikol as enhancers the physical characteristics, drug release and assess the ability of simvastatin on the optimum formula. Factorial design method 23 applied to optimize the mucoadhesive buccal patches of simvastatin use factor carbopol 934P, HPMC and Propilenglikol as independent variables. mucoadhesive buccal patches of simvastatin were prepared by solvent casting method. Patch subjected for physicochemical characterization test such as weight, weight variation, dimansions, thickness, folding endurance, surface pH, swelling index, time and mucoadhesive strangth, drug content, stability in saliva simulation and in vitro drug release study. Optimized mucoadhesive buccal patches of simvastatin formulation were subjected for drug permeation through sheep buccal mucosa on 8 hour. Carbopol 934P significantly increase the swelling index, time and mucoadhesive strenght. HPMC significantly decrease the swelling index, time and mucoadhesive strangth. Propilenglikol significantly increasing in vitro drug release. In vitro drug permeation was found 21.34 ± 0.33% in 8 h. Lag time 0,8 h, fluks 0.146 mg.cm-2.hour-1, and diffusion coefficient 8,33.10-3 cm2.jam-1. It can be concluded that buccal route can be one of the alternatives available for administration of simvastatin. Keywords: Simvastatin, Carbopol, HPMC, buccal patches, permeation

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Simvastatin, Carbopol, HPMC, buccal patches, permeation
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 14 Oct 2019 04:40
Last Modified: 14 Oct 2019 04:40
URI: http://repository.setiabudi.ac.id/id/eprint/2031

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