FORMULASI TABLET KUNYAH EKSTRAK ETANOL KULIT BUAH NAGA SUPER MERAH (Hylocereus costaricensis) SEBAGAI ANTIOKSIDAN DENGAN KOMBINASI MANITOL DAN PVP K.30 SECARA GRANULASI BASAH

SILALAHI, Dian Alprida (2015) FORMULASI TABLET KUNYAH EKSTRAK ETANOL KULIT BUAH NAGA SUPER MERAH (Hylocereus costaricensis) SEBAGAI ANTIOKSIDAN DENGAN KOMBINASI MANITOL DAN PVP K.30 SECARA GRANULASI BASAH. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Super red dragon fruit are particular as antioxidant. Chewable tablet of super red dragon fruit peels is a practical and effective dossage form. This study was aimed to find out whether the extract of super red dragon fruit peels could be made chewable tablet with PVP K.30 binder, and to know the effect of PVP K.30 and mannitol on the physical properties of a chewable tablet, and was there any difference value of IC50 extract with chewable tablet. Super red dragon fruit peels were macerated with ethanol 70%, and then filtered and evaporated to obtain viscous extract, and then were conducted for its qualitative identification by TLC and proven that contains flavonoid, polyphenol and saponin. The extract was made into five formulas based on different concentrations of PVP K.30 and mannitol, by wet granulation method. The obtained granules were tested for its flowing time, the angle of repose and moisture level. The chewable tablets were tested the physical properties, weight uniformity, friability, hardness and taste response. Test of antioxidant activity of the extract and chewable tablet was done with DPPH method, which could be measured by UV-Vis spectroscopy at λ max then calculated IC50. The obtained data were analyzed by one way ANOVA. The conclusion of this study were dragon fruit peel extract could be made chewable tablet with binder PVP K.30, combination of PVP K.30 and mannitol affected the physical quality of the tablet, there was a difference between the antioxidant activity of the extract with chewable tablet, IC50 values of each extract and chewable tablet formula is 416.862; F1: 461, 785; F2: 464.999; F3: 474.551; F4: 506.144; F5: 539.928. Keywords: antioxidant, chewable tablet, super red pitaya (Hylocereus costaricencis) peels, PVP K.30, Mannitol

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: antioxidant, chewable tablet, super red pitaya (Hylocereus costaricencis) peels, PVP K.30, Mannitol
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Mrs NOVI HANDAYANI
Date Deposited: 14 Oct 2019 04:23
Last Modified: 14 Oct 2019 04:23
URI: http://repository.setiabudi.ac.id/id/eprint/2003

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