OPTIMASI PROPORSI KOMBINASI CARBOPOL 940 DAN GLISERIN DALAM FORMULA GEL LENDIR BEKICOT (Achatina fulica Ferr) SEBAGAI ANTIBAKTERI Staphylococcus aureus ATCC 25923 DENGAN METODE SIMPLEX LATTICE DESIGN

SUMULE, Arsiaty (2015) OPTIMASI PROPORSI KOMBINASI CARBOPOL 940 DAN GLISERIN DALAM FORMULA GEL LENDIR BEKICOT (Achatina fulica Ferr) SEBAGAI ANTIBAKTERI Staphylococcus aureus ATCC 25923 DENGAN METODE SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Escargot mucus (Achatina fulica ferr) containing protein achasin that has antibacterial activity in healing wounds. The content of escargot antibacterial peptide could inhibit Staphylococcus aureus ATCC 25923 is mytimacin-AF. The escargot mucus is less practical if using directly, so that a gel preparation is made. This research aimed to get the optimum proportion of Carbopol 940-glycerin and antibacterial activity of optimum formula that tested against Staphylococcus aureus ATCC 25923. The escargot mucus gel made three formulas with the composition of Carbopol 940 1%, 1,5%, 2% and glycerin 15%, 14,5%, 14%. Each formula is tested during 4 weeks for its physical properties include organoleptic, homogeneity, viscosity, spreadability, adhesion, and viscosity shift. The result are optimized by the simplex lattice design using Design Expert 8.0.6.1 to obtain the optimum formula. The optimum formula is made and tested its physical properties for 4 weeks. Prediction and experimental results were analyzed by one sample ttest. The antibacterial testing of optimum formula using diffusion wells and were analyzed by one way anova. The result of research on the optimum formulation of escargot mucus gel was obtained in Carbopol 940 1,123% and glycerin 14,877%. Physical response of the optimum formula prediction and experimental results showed no significant difference. The optimum formula has antibacterial activity with inhibition diameter 1.73 cm. Keywords: Escargot (Achatina fulica Ferr) mucus, simplex lattice design, gel, Carbopol 940, glycerin

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Escargot (Achatina fulica Ferr) mucus, simplex lattice design, gel,Carbopol 940, glycerin
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Mrs NOVI HANDAYANI
Date Deposited: 10 Oct 2019 08:35
Last Modified: 10 Oct 2019 08:35
URI: http://repository.setiabudi.ac.id/id/eprint/1987

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