AKTIVITAS ANTIHIPERGLIKEMIK KOMBINASI MINYAK BIJI MAHONI (Swietenia mahagoni Jacq) DAN METFORMIN TERHADAP PENURUNAN KADAR GULA DARAH TIKUS JANTAN DENGAN RESISTENSI INSULIN

PUTRI, Ajeng Octaviana Anggraeni (2015) AKTIVITAS ANTIHIPERGLIKEMIK KOMBINASI MINYAK BIJI MAHONI (Swietenia mahagoni Jacq) DAN METFORMIN TERHADAP PENURUNAN KADAR GULA DARAH TIKUS JANTAN DENGAN RESISTENSI INSULIN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Mahogany seed lots examined activity as antihyperglycemic with the chemical content of flavonoids, alkaloids, and saponins. This research aims to prove mahogany seed oil has a antihyperglycemic activity and to find out if the combination of metformin and a mahogany seed oil is effective to decrease blood sugar levels of rats with insulin resistance. The test animals used were Rattus norvegicus that were fed high fat diet for 2 months. Rats were divided into 7 groups. The first group as normal group, the group as a group of insulin resistance, the third group given a mahogany seed oil 2,35 ml/200 gram BB, the fourth group was given metformin 9 mg/200 gram BB, the fifth group was given a combination of metformin and a mahogany seed oil 1,8 ml/200 gram BB: 2,25 mg/200 gram BB, the sixth group of mahogany and seed oil was given metformin 1,2 ml/200 g BB : 4,5 mg/200 gram BB, the seventh group was given metformin mahogany and seed oil of 0,6 ml/200 gram BB: 6,75 mg/200 gram BB. The administration of mahogany seed oil, and metformin combination was done twice a day for 2 days and observations done every day. The data obtained were analyzed with one way ANOVA (significant set at p < 0.05). The results showed that mahogany seed oil not have antihyperglycemic activity and all comparison combination cannot to decrease blood sugar levels first days after given. Keywords : Swietenia mahagony Jacq, metformin, insulin resistance, high fat diet, antidiabetic.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Swietenia mahagony Jacq, metformin, insulin resistance, high fat diet, antidiabetic
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Mrs NOVI HANDAYANI
Date Deposited: 10 Oct 2019 08:35
Last Modified: 10 Oct 2019 08:35
URI: http://repository.setiabudi.ac.id/id/eprint/1979

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