FORMULASI DAN UJI MUTU FISIK SUSPENSI ERITROMISIN DENGAN VARIASI SUSPENDING AGENT PGA (Pulvis Gummi Arabic) DAN Na- CMC (Natrium Carboxymethylcellulosum)

Simatupang, Shintya Sri Rezeki (2016) FORMULASI DAN UJI MUTU FISIK SUSPENSI ERITROMISIN DENGAN VARIASI SUSPENDING AGENT PGA (Pulvis Gummi Arabic) DAN Na- CMC (Natrium Carboxymethylcellulosum). Karya Tulis Ilmiah thesis, Universitas Setia Budi Surakarta.

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Abstract

Suspension is a medicinal preparation containing solid material in the form of subtle and insoluble, dispersed in a liquid carrier. Erythromycin antibiotics is one of Makrolida which is not dissolves in water so that it is made in preparation of the suspension. This study was aimed to find out how was the influence of suspending agent PGA and Na-CMC on the physical properties of Erythromycin, as well as to find out what concentration that could provide the most excellent physical quality among five formulas. Erythromycin suspension was made preparations in five different formulations. The difference of the formulations was on the concentrations of suspending agent that used. Variation of the concentration of the PGA and Na-CMC from formula 1, 2, 3, 4 and 5 are (4% and 0%); (2.75% and 0.25%); (1.5% and 0.5%); (0.25% and 0.75%); (0% and 1%). Suspension which has been created then done physical quality testing includes of: volume of sedimentation, viscosity, pH, easily whether or not the cast, and redispersibility. The test results are compared with other formulas and in analysis using One Way Anova test followed Post Hoc Tukey Tests 95% confidence levels to find out the best suspension formula and stable during storage. The results showed that the variation of the suspending agent affected on physical quality test suspension. Formula no. 4 based on results of testing physical quality cream has the best stability of five suspension formula made with concentrations of suspending agent PGA and Na-CMC are 0.25% and 0.75%. Keyword: Suspension, Erythromycin, Suspending agent, PGA, Na-CMC.

Item Type: Thesis (Karya Tulis Ilmiah)
Uncontrolled Keywords: Suspension, Erythromycin, Suspending agent, PGA, Na-CMC.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi D3 Farmasi
Depositing User: magdalena kartika ningsih
Date Deposited: 10 Oct 2019 04:35
Last Modified: 10 Oct 2019 04:35
URI: http://repository.setiabudi.ac.id/id/eprint/1767

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