FORMULASI TABLET HISAP SARI BUAH SIRSAK (Annona muricata Linn) DENGAN KOMBINASI BAHAN PENGISI MANITOL DAN LAKTOSA

Kriesthy, January (2016) FORMULASI TABLET HISAP SARI BUAH SIRSAK (Annona muricata Linn) DENGAN KOMBINASI BAHAN PENGISI MANITOL DAN LAKTOSA. Karya Tulis Ilmiah thesis, Universitas Setia Budi Surakarta.

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Abstract

Soursop not always already in every season and the storage relatively short so made lozenges in order more effectivel and practic its use as well as easy obtain. Soursop contain high polyphenol and flavonoid compounds which have afficacy as antioxidant in the body. Antioxidant is very good for increase immune system, help to resist free radicals that enter the body and prevent or slow the aging process. Soursop taken the essense and then dried in oven at temperature 50-60°C with the addition of maltodextrin as desiccant. This study was aimed to determine the combination of mannitol and lactose fillers of the lozenges formula of soursop essense to the physical properties of tablet. Soursop pollen was made dilution from soursop that blended then dried by maltodextry. Lozenges was made in three formulas, those are F I with combination of mannitol 25% - lactose 75%, F II with combination of mannitol 50% - lactose 50% and F III with combination of mannitol 75% - lactose 25%. Production of lozenges with wet granulation. The granule obtained was tested physical properties include: flow time, repose angle and drying shrinkage. The tablet results which obtained was tested the physical properties of tablet include: weight uniformity, hardness, friability, taste response and dissolve time test. The data obtained were analyzed statistically using ANOVA test. The study results lozenges of soursop essense with combinations of mannitol and lactose show all formulas were able to produce lozenges that meet the requirements of granule properties and physical properties of tablet. Combination of mannitol and lactose fillers could affect to physical properties of soursop lozenges. The most accepted lozenges by respondent was Formula II. Keywords: soursop, lozenges, mannitol, lactose.

Item Type: Thesis (Karya Tulis Ilmiah)
Uncontrolled Keywords: soursop, lozenges, mannitol, lactose.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi D3 Farmasi
Depositing User: magdalena kartika ningsih
Date Deposited: 10 Oct 2019 04:31
Last Modified: 10 Oct 2019 04:31
URI: http://repository.setiabudi.ac.id/id/eprint/1743

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