UJI AKTIVITAS ANTIDIABETES EKSTRAK AIR TANAMAN ANTINGANTING (Acalypha australis L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI ALOKSAN

MONICA, Shella (2015) UJI AKTIVITAS ANTIDIABETES EKSTRAK AIR TANAMAN ANTINGANTING (Acalypha australis L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Acalypha have some chemical content which nutritious, such are flavonoid, saponin, alkaloid, and phenol, so it can be used as herb drug. The result of previous studies acalypha is a plant that is used for the treatment of diabetes. This study was aimed to determine antidiabetic activity water extract of acalypha plant, and to find out effective dose in decrease blood glucose level. Extraction done by maceration method using solvent water. The test method used was alloxan diabetes. Animal test was divided into 5 groups, each group consist of 5 male rats, namely: Group I negative control (CMC 0.5%), Group II drug control (glibenclamide) with dose 0.09 mg/200 g BW rat, and Group III, IV, V given doses of water extract of acalypha herb 30 mg/200 g BW rat, 60 mg/200 g BW rat, 120 mg/200 g BW rat, respectively. All groups induced alloxan on day 0 (after fasted for 16 hours) intraperitoneally. Treatment was given 3 days after alloxan induction. Examination of blood sugar level was conducted on day 3rd, 6th, 9th, 12th, and 15th after administration of preparation test. The test results showed that water extract of acalypha herb dose 30 mg/200 g BW rat, dose 60 mg/200 g BW rat, dose 120 mg/200 g BW rat could decrase blood glucose level. Water extract of acalypha herb dose 60 mg/200 g BW rat was effective in decrease blood glucose level. Keywords : Acalypha australis Linn, alloxan, antidiabetic, water extract

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Acalypha australis Linn, alloxan, antidiabetic, water extract
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 03 Oct 2019 04:31
Last Modified: 03 Oct 2019 04:31
URI: http://repository.setiabudi.ac.id/id/eprint/1596

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