EFEK ANTIINFLAMASI EKSTRAK ETANOL DAUN Angelica keiskei (Miq.) Koidz TERHADAP TIKUS PUTIH JANTAN Rattus norvegicus

MU'IZ, Resta Daniel (2015) EFEK ANTIINFLAMASI EKSTRAK ETANOL DAUN Angelica keiskei (Miq.) Koidz TERHADAP TIKUS PUTIH JANTAN Rattus norvegicus. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Inflammation is a response toward damaged tissue due to several harm stimulations either chemicals or mechanics, and infection from bacteria or virus. Angelica keiskeileaf contains alkaloid, saponin, tannin, phenolic, flavonoid, terpenoid, glycoside and steroid. The aim of this research was to find out the antiinflammation effect of Angelica keiskei ethanol extract. Animal model was adapted during 18-24 hours before used for research. Animal model was divided 5 groups i.e. Group I was given CMC 1%, Group II was given diclofenac sodium. A 150, 300, and 600 mg/kg body weight (BW) of Angelica keiskei leaf ethanol extract were given for Group III, IV, and V, respectively. After treatment all groups were induced by carrageenan 1% in rat’s foot, after 30 minutes edema volume was measured at 1,2,3,4 and 5 hours. From edema volume data were obtained area under curve (AUC) value and percentage of anti-inflammation power. The results showed that ethanol extract of Angelica keiskeihad antiinflammation effect on Wistar male rat. The Angelica keiskeiethanol extract of 150, 300 and 600 mg/kg BW had anti-inflammation power of 41.90, 37.99 and 32.84%, respectively. The Angelica keiskeidose of 150 mg/kg BW had the most effective anti-inflammation activity. keywords: Asitaba leaf ( Angelica keiskei (Miq.) Koidz), anti-inflammation, carrageenan

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Asitaba leaf ( Angelica keiskei (Miq.) Koidz), anti-inflammation, carrageenan
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 03 Oct 2019 03:49
Last Modified: 03 Oct 2019 03:49
URI: http://repository.setiabudi.ac.id/id/eprint/1587

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