EFEK ANTI INFLAMASI EKSTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) TERHADAP EDEMA KAKI TIKUS PUTIH JANTAN YANG DIINDUKSI KARAGENIN

RUSDARYANTI, Rantika (2015) EFEK ANTI INFLAMASI EKSTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) TERHADAP EDEMA KAKI TIKUS PUTIH JANTAN YANG DIINDUKSI KARAGENIN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Inflammation is a normal protective response against tissue injuries caused by physical trauma, destructive chemicals or microbiological substances. The content of flavonoids in the pandan wangi leaves was known to have a antiinflammatory activity. The purpose of this study was to determine the antiinflammatory effect of ethanol extract pandan wangi leaves. This study used 25 rats and were divided into 5 groups: the negative control (CMC 1%), positive control (Na-dichlophenac), doses of ethanol extracts pandan wangi leaves 18 mg/kg BW, 36 mg/kg BW and 54 mg/kg BW. Each rats induced by karagenin 1% injection on the sole of the feet rats by subplantar. Then measured the volume of edema from hours 0; 1; 2; 3; 4 and 5. The result was measured for Edema volume of research data from the value of the AUC and % anti-inflammatory resources. The results showed that ethanol extract of pandan wangi leaves have antiinflammatory effect on male rats strain wistar. The dose of ethanol extracts pandan wangi leaves 18 mg/kg BW, 36 mg/kg BW and 54 mg/kg had a AUC values in a row are 0.094 ml/hour; 0,101 ml/hour; 0,103 ml/hours and percent DAI 49.78%; 45,35%; 44,08%. The ethanol extract pandan wangi leaves dose of 18 mg/kgBB had the most effective anti-inflammatory effects. Key words: pandan wangi leaves, ethanol extract, Anti-inflammatory, Karagenin.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: pandan wangi leaves, ethanol extract, Anti-inflammatory, Karagenin.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 03 Oct 2019 03:49
Last Modified: 03 Oct 2019 03:49
URI: http://repository.setiabudi.ac.id/id/eprint/1586

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