OPTIMASI FORMULA KOMBINASI PENGISI MANITOL DAN PENGHANCUR CROSPOVIDON DALAM PEMBUATAN FAST DISSOLVING TABLET FAMOTIDIN DENGAN METODE FACTORIAL DESIGN

SOLEHKAWATI, Nur Ayu (2015) OPTIMASI FORMULA KOMBINASI PENGISI MANITOL DAN PENGHANCUR CROSPOVIDON DALAM PEMBUATAN FAST DISSOLVING TABLET FAMOTIDIN DENGAN METODE FACTORIAL DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Famotidine is histamine H2-receptor.Famotidine was widely used for gastric ulcers, duodenal ulcers, Zollinger-Ellison syndrome and gastroesophageal reflux disease.Famotidine is made in the preparation of fast-dissolving tablet that can disintegrate quickly in the saliva fluids without the use of water and provide good taste.The study purposes were determined the effect of the combination of Crospovidon and Mannitol on the physical properties of FDT famotidine and get comparison of Crospovidon and Mannitol which can provide optimum physical properties and flavor of FDT famotidine by the factorial design method. This study was conducted using four formulas variation of combination of mannitol and crospovidon. The tablets were compressed using direct press and conducted testing on the physical properties of the granules, tablets, and drug release. The factorial design method was applied to optimize tablet.The determination of the optimum formula was used counter plot of parameters of flow time and, dissolved time, wetting and dissolution was used software of Design Expert Version 8.0.6. The results were showed that the interaction of crospovidon and mannitol can increase dissolved time and drug release and can provide good taste.Based on the counter plot was obtained the optimum formula of FDT famotidine tablets with the combination of 50 mg mannitol and 10 mg crospovidon. The response of physical properties of the optimum formula of predictions and experimental results were showed no significant difference. Keywords: fast dissolving tablets, factorial design, famotidine, mannitol.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: fast dissolving tablets, factorial design, famotidine, mannitol.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 03 Oct 2019 03:49
Last Modified: 03 Oct 2019 03:49
URI: http://repository.setiabudi.ac.id/id/eprint/1581

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