SKRINING EFEK HEPATOPROTEKTOR FRAKSI-FRAKSI DAUN PEPAYA (Carica papaya L.) PADA TIKUS JANTAN WISTAR

SUCININGTYAS, KHARISMA NILA GALUH (2015) SKRINING EFEK HEPATOPROTEKTOR FRAKSI-FRAKSI DAUN PEPAYA (Carica papaya L.) PADA TIKUS JANTAN WISTAR. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Papaya leaf is one of the plant use as a hepatoprotective because it contains flavonoids, alkaloids and saponin. This study aimed to determine the effect of n-hexane fractions, ethyl acetate fractions and water fractions of 96% ethanol extract of papaya leaf against the percentage necrosis of liver cells. Thirty five rats were divided into 7 group. Group I was normal control were given 1% CMC suspension. Group II was negative control group. Group III was positive control group were given curcuma tablets suspension with doses 3,6 mg/200 g BW. Group IV, V, VI and VII as the treatment group (96% ethanol extracts of carica papaya leaf, n-hexane fraction, ethyl acetate fraction and water fraction respectively) with doses 60 mg/ 200 g BW. Treatment for 8 days, started at day-4 to day-8 all group except normal controls, given a INH and Rifampicin dose 10 mg/200 g BW after 2 hours of the extract and fractions. On day 8th, 4 hours after INH and Rifampicin induction, the test animals were sacrified, take the liver, made histological preparations. The data obtained were analyzed by Oneway Anova. The experiment showed the liver necrosis n-hexane fractions 22,5%, etyl acetate fractions 10,75% and water fractions 20%. According to Oneway Anova, it was obtained that there was significant difference between the treatments. The conclude of this experiment is etyl acetate fractions was effective as hepatoprotector. Key word : papaya leaf, INH-rifampisin, necrosis.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: papaya leaf, INH-rifampisin, necrosis.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:43
Last Modified: 01 Oct 2019 03:43
URI: http://repository.setiabudi.ac.id/id/eprint/1566

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