AKTIVITAS ANTI-INFLAMASI EKSTRAK ETANOL DAUN MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl.) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI KARAGENIN

PRAYOGA, Januar Dwi Hendra (2015) AKTIVITAS ANTI-INFLAMASI EKSTRAK ETANOL DAUN MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl.) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI KARAGENIN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Inflammatory is a response toward damaged tissue due to several harm stimulations either chemicals or mechanics, and infection from bacteria or virus. Phaleria macrocarpa leaf contais alkaloid, saponin, polifenol and flavonoid. This research aimed at determining the anti-inflammatory effect of mahkota dewa ethanolic extract on Wister male rat that has been induced carrageenan and determining the doses variations of mahkota dewa leaf extract on the effect of anti-inflammation. Phaleria (Phaleria macrocarpa) was extracted by maceration method using ethanol 96%. The anti-inflammatory effect testing was done using 25 rats with edema method on bottom part of foot that has been induced by carrageenan 1%. The animal model was divided by five groups i.e. Na CMC 1%, mahkota dewa leaf ethanolic extract of 25, 50, 100 mg/kg BW, and diclofenac sodium for group 1,2,3,4, and 5, respectively. The measurement was conducted after one hour of 1% of carrageenan induction on bottom part of foot intraplantarly. The results were measured during six hours and calculated AUC value and percentage of antiinflammatory activity. The result showed that mahkota dewa leaf ethanolic extract had antiinflammatory activity on Wistar male rats. The doses of mahkota dewa leaf ethanolic extract of 25, 50, 100 mg/200 g BW had anti-inflammatory activity of 31.42, 34.48, and 37.14%, respectively. The doses of mahkota dewa leaf ethanolic extract of 25, 50, 100 mg/200 g BW had anti-inflammation activity closed to diclofenac sodium. Keywords: anti-inflammation, mahkota dewa leaf ethanolic extract, carrageenan

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: anti-inflammation, mahkota dewa leaf ethanolic extract, carrageenan
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:38
Last Modified: 01 Oct 2019 03:38
URI: http://repository.setiabudi.ac.id/id/eprint/1561

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